某三甲医院住院患者血栓事件的横断面分析及其抗磷脂抗体情况  

Cross-Sectional Analysis of Thrombus Events and Antiphospholipid Antibodies of Inpatients in a Tertiary Hospital

作　　者：张博林[1] 杨丽萍 杨耀 ZHANG Boin;YANG Liping;YANG Yao(Department of Laboratory Medicine,Guangyuan Central Hospital,Guangyuang 628000,China)

机构地区：[1]广元市中心医院检验科,四川广元628000

出　　处：《中国医药指南》2023年第22期1-5,共5页Guide of China Medicine

基　　金：广元市科技计划项目(编号:20ZDYF0008)。

摘　　要：目的进行住院患者血栓事件的横断面研究并分析抗磷脂抗体(aPL)在伴有血栓事件的住院患者中的表达。方法选取我院2021年1月至2021年10月住院期间发生血栓事件的患者共235例为血栓组,对血栓组的临床资料进行横断面分析。同时选取同时期健康体检人群120例为对照组,比较两组的狼疮抗凝物(LA)、抗心磷脂抗体(ACL)和抗β_(2)糖蛋白Ⅰ抗体(aβ_(2)GPⅠ)情况。结果血栓组平均年龄为67(56~76)岁,其中≥60岁的患者占63.0%(148/235)。血栓患者主要分布在骨科(35.3%)及心血管外科(20.9%),其次为心血管内科、呼吸科及ICU,原发疾病主要包括创伤性损伤(33.6%)和心脑血管疾病(30.2%)。235例患者的血栓事件包括单纯静脉血栓154例(65.5%),单纯动脉血栓42例(17.9%),多部位血栓39例(16.6%)。静脉血栓事件主要表现为下肢深静脉血栓(DVT),动脉血栓事件主要表现为急性冠状动脉综合征(ACS),多部位血栓主要为DVT合并肺动脉栓塞。血栓组aPL阳性率为25.5%,LA、ACL和aβ_(2)GPⅠ的阳性率分别为13.6%、14.0%、11.1%,单阳性率、双阳性率及三阳性率分别为14.5%、8.9%和2.1%。单纯静脉血栓的ACL阳性率、aβ_(2)GPⅠ阳性率及ACL+aβ_(2)GPⅠ双阳性率均明显高于健康对照组。多部位血栓的LA阳性率明显高于健康对照组。结论住院患者血栓事件的发生在年龄、科室、原发疾病、血栓类型等方面存在明显特征。尽管ACL、aβ_(2)GPⅠ和LA与血栓形成关系密切,但因其阳性率低,不建议对伴有血栓事件的住院患者进行aPL常规检查。Objective To conduct a cross-sectional study on clinical data in the hospitalized patients with thrombotic events and investigate the expression of anti-phospholipid antibodies(aPL) in them.Methods A total of 235 patients with thrombus events during hospitalization in our hospital from January 2021 to October 2021 were selected as the thrombus group.At the same time,120 healthy subjects were selected as control group.The lupus anticoagulant(LA),anti-cardiolipin antibody(ACL) and anti-β_(2)-glycoproteinⅠantibodies(aβ_(2)GPⅠ) were tested in both groups.Results The mean age of thrombus group was 67 years old,among which 63.0%(148/235) were 60 years old or older.The thrombus patients were mainly from orthopedics(35.3%) and cardiovascular surgery(20.9%),followed by cardiovascular medicine,respiratory medicine and ICU.The primary diseases mainly included traumatic injury(33.6%) and cardiovascular and cerebrovascular diseases(30.2%).The thrombotic events of 235patients included 154 cases(65.5%) of simple venous thrombosis,42 cases(17.9%) of simple arterial thrombosis,and 39 cases(16.6%) of multiple embolic events.The most common venous thrombosis event was deep venous thrombosis(DVT),arterial thrombosis event was acute coronary syndrome(ACS),and the multiple embolic event was DVT combined with pulmonary embolism(PE).In the thrombus group,the total positive rate of aPL was 25.5%,while the positive rate of LA,ACL and aβ_(2)GPⅠ were 13.6%,14.0% and 11.1%,respectively.Meanwhile,the single,double and triple positive rates were 14.5%,8.9% and 2.1%,respectively.The positive rate of ACL,aβ_(2)GPⅠ and ACL+ aβ_(2)GPⅠ in the simple venous thrombosis subgroup were higher than those in the control group.The positive rate of LA in the multiple thrombus subgroup was higher than that in the control group.Conclusions The hospitalized patients with thrombotic events had obvious characteristics in age,department,primary disease,thrombus type and so on.Although ACL,aβ_(2)GPⅠ and LA are closely associated with thrombosis,a

关 键 词：血栓事件 抗磷脂抗体 横断面研究 

分 类 号：R743[医药卫生—神经病学与精神病学]