血浆 Septin9 基因甲基化检测对结直肠癌诊断的价值研究  被引量:1

The value of plasma methylated Septin9 detection in the diagnosis of colorectal cancer

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作  者:陆飞燕 陆相磊 岑小宁 黄春程 黄林达 龙喜带[1,3,4] 朱晓莹 Lu Feiyan;Lu Xianglei;Cen Xiaoning;Huang Chuncheng;Huang Linda;Long Xidai;Zhu Xiaoying(Clinical Pathological Diagnosis and Research Centre,The Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;Department of Gastrointestinal Surgery,The Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;The Key Laboratory of Molecular Pathology of Hepatobiliary Diseases of Guangxi,Baise 533000,Guangxi,China;The Key Laboratory of Tumor Molecular Pathology of Guangxi Colleges and Universities,Baise 533000,Guangxi,China)

机构地区:[1]右江民族医学院附属医院临床病理诊断与研究中心,广西百色533000 [2]右江民族医学院附属医院胃肠外科,广西百色533000 [3]广西肝胆疾病分子病理学重点实验室,广西百色533000 [4]广西高校肿瘤分子病理学重点实验室,广西百色533000

出  处:《右江民族医学院学报》2023年第4期626-629,634,共5页Journal of Youjiang Medical University for Nationalities

基  金:百色市科学研究与技术开发计划项目(百科字〔2021〕32号),广西临床重点专科(病理)建设项目(桂卫医发〔2022〕21号)。

摘  要:目的探讨血浆中Septin9基因甲基化(methylated Septin 9,mSEPT9)检测在结直肠癌(colorectal cancer,CRC)诊断中的应用价值。方法收集2020年5月至2022年4月在右江民族医学院附属医院收治并经病理学诊断为非CRC患者42例和CRC患者129例,分别作为非CRC组和CRC组,分析患者血浆mSEPT9检测、大便隐血试验(FOBT)、癌胚抗原(CEA)和CA199检测结果,评价其单项检测和基于血浆mSEPT9的联合检测在CRC诊断中的应用价值。结果①CRC组mSEPT9检测阳性率为58.14%(75/129),非CRC组mSEPT9检测阳性率为19.05%(8/42),两组差异具有统计学意义(P<0.001)。②血浆mSEPT9检测CRC的敏感度为58.14%,高于CEA(39.53%)和CA199(19.38%);特异度为80.95%,高于FOBT(47.62%),基于血浆mSEPT9检测的联合检测敏感度均高于其单项检测。结论mSEPT9检测在CRC诊断中具有较高的敏感性和特异度,基于mSEPT9的联合检测敏感度高于单项检测,是CRC诊断重要的辅助手段。Objective To explore the value of plasma methylated Septin 9(mSEPT9)detection in the diagnosis of colorectal cancer(CRC).Methods A total of 42 patients with non CRC and 129 patients with CRC who were admitted to the Affiliated Hospital of Youjiang Medical College for Nationalities from May 2020 to April 2022 and diagnosed pathologically were collected,and they were divided into non-CRC group and CRC group.The results of plasma mSEPT9 detection,fecal occult blood test(FOBT),carcino embryonic antigen(CEA),and CA199 detection were analyzed,and the value of single detection and combined detection based on plasma mSEPT9 in the diagnosis of colorectal cancer were evaluated.Results①The positive rate of mSEPT9 detection was 58.14%(75/129)in colorectal cancer group and 19.05%(8/42)in non-CRC group,and the difference between the two groups was statistically significant(P<0.001).②The sensitivity of plasma mSEPT9 detection for CRC was 58.14%,higher than that of CEA(39.53%)and CA199(19.38%);the specificity of plasma mSEPT9 detection was 80.95%,higher than that of FOBT(47.62%),and the sensitivity of the combined detection based on plasma mSEPT9 was higher than that of the single detection.Conclusion mSEPT9 detection has high sensitivity and specificity in the diagnosis of CRC,and the combined detection based on mSEPT9 is more sensitive than the single detection,which is an important auxiliary means for the diagnosis of CRC.

关 键 词:Septin9基因甲基化 结直肠肿瘤 大便隐血 癌胚抗原 

分 类 号:R735.3[医药卫生—肿瘤]

 

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