原发性肝癌患者介入治疗后血清LOXL4水平与复发的相关性分析  

Correlation analysis between serum LOXL4 level and recurrence in patients with primary liver cancer after interventional therapy

作　　者：高越[1] 万里新[1] 曾庆[1] 池盟盟 邓俊魁 GAO Yue;WAN Li-xin;ZENG Qing(Department of Radiology,Nanyang Central Hospital(Nanyang Henan.473005),China.)

机构地区：[1]南阳市中心医院放射科,河南南阳473005

出　　处：《中西医结合肝病杂志》2023年第8期698-701,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：河南省医学科技攻关计划项目(No.222102310221);。

摘　　要：目的:检测原发性肝癌(PHC)患者介入治疗后血清赖氨酰氧化酶样蛋白4(LOXL4)水平,并分析其与复发的关系。方法:选取2018年1月至2022年1月就诊并确诊为PHC的97例患者为研究组,根据介入治疗6个月后是否复发分为复发组(n=40)和未复发组(n=57),选取进行健康体检的志愿者90例为对照组。收集所有对象的一般资料,采用实时荧光定量PCR法检测血清中LOXL4表达水平,Spearman法分析LOXL4表达水平与PHC患者介入治疗后复发的相关性,用受试者工作特征(ROC)曲线评价血清LOXL4水平对PHC患者介入治疗后复发的预测价值,采用多因素Logistic回归分析PHC患者介入治疗后复发的影响因素。结果:与未复发组比较,复发组患者血清中LOXL4水平明显升高(P<0.05),分化程度低、淋巴结转移占比均较高(P<0.05)。Spearman相关性分析结果显示,血清中LOXL4水平与PHC患者介入治疗后复发呈正相关(r=0.680,P<0.05);ROC曲线结果显示,血清LOXL4水平预测PHC患者介入治疗后复发的曲线下面积(AUC)为0.918(95%CI=0.773~0.922),对应的敏感度为85.00%,特异度为92.98%;多因素Logistic回归分析显示,LOXL4、淋巴结转移、分化程度是PHC患者介入治疗后复发的影响因素(P<0.05)。结论:LOXL4在复发的PHC患者血清中表达上调,可有效帮助预测患者的复发情况。Objective:To detect the level of serum lysyl oxidase-like 4(LOXL4)in patients with primary liver cancer after interventional therapy,and to analyze its relationship with recurrence.Methods:From January 2018 to January 2022,97 patients who were diagnosed with primary liver cancer were regarded as the research group.According to the recurrence or not after 6 months of interventional therapy,they were grouped into recurrence group(n=40)and non-recurrence group(n=57).In addition,90 volunteers who underwent physical examination were regarded as the control group.General data were collected,and the expression level of LOXL4 in serum was detected by real-time fluorescence quantitative PCR.Spearman method was performed to analyze the correlation between the expression level of LOXL4 and the recurrence of primary liver cancer after interventional therapy;while receiver operating characteristic(ROC)curve was performed to evaluate the predictive value of serum LOXL4 level for recurrence after interventional therapy in patients with primary liver cancer;multivariate Logistic regression analysis was performed to analyze the influencing factors of recurrence after interventional therapy in patients with primary liver cancer.Results:Compared with the non-recurrence group,the serum LOXL4 level in the recurrence group was obviously increased(P<0.05);while the recurrence group had a lower degree of differentiation and a higher proportion of lymph node metastasis(P<0.05).Spearman correlation analysis showed that serum LOXL4 level was positively correlated with recurrence after interventional therapy in patients with primary liver cancer(r=0.680,P<0.05).ROC curve results showed that the area under the curve(AUC)of serum LOXL4 level in predicting the recurrence of primary liver cancer patients after interventional therapy was 0.918(95%CI:0.773-0.922),the corresponding sensitivity was 85.00%,and the specificity was 92.98%.Multivariate logistic regression analysis showed that LOXL4,lymph node metastasis and degree of differentiation we

关 键 词：原发性肝癌 赖氨酰氧化酶样蛋白4 复发 相关性 

分 类 号：R735.7[医药卫生—肿瘤]