唐草片治疗19例艾滋病合并代偿期肝硬化患者的临床观察  

Clinical observation of Tang Herb in the treatment of 19 AIDS patients with compensated cirrhosis

作　　者：许琪华 陈思言 林路平[1] 邵宝平 谭行华[1,2] XU Qi-hua;CHEN Si-yan;LIN Lu-ping(Hepatology department of Integrated traditional Chinese and western medicine,Guangzhou eighth people′s hospital,Guangzhou Medical University(Guangdong Guangzhou,510060),China.)

机构地区：[1]广州医科大学附属市八医院中西医结合肝病科,广东广州510060 [2]广州中医药大学青蒿研究中心 [3]上海百岁行药业有限公司

出　　处：《中西医结合肝病杂志》2023年第8期702-704,709,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：“十三五”国家科技重大专项(No.2018ZX10303502)。

摘　　要：目的:观察唐草片治疗艾滋病(AIDS)合并代偿期肝硬化患者的临床疗效。方法:采用自身前后对照研究方法,纳入AIDS合并乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)感染后肝硬化患者19例,给予唐草片治疗24周,于基线、治疗12周及24周观察患者血常规、肝肾功能、肝纤维化五项、肝脏硬度值、免疫细胞功能及HIV-1 RNA的变化。结果:与基线相比,患者治疗12周及24周白细胞计数(WBC)、血红蛋白(Hgb)、血小板(PLT)有所升高,差异均无统计学意义,治疗24周后患者白蛋白(Alb)上升,丙氨酸氨基转移酶(ALT)及天门冬氨酸氨基转移酶(AST)水平下降,差异均有统计学意义(P<0.05,P<0.01);直接胆红素(TBil)、间接胆红素(DBil)、肌酐(Cr)有所下降,球蛋白(Glb)、前白蛋白(PA)、胆碱酯酶(CHE)水平有所上升,但差异均无统计学意义(P>0.05);患者治疗12周及24周Ⅲ型前胶原N端肽(PⅢP)降低,差异有统计学意义(P<0.01);透明质酸(HA)、层黏连蛋白(LN)、Ⅳ型胶原(CⅣ)有不同程度降低,差异无统计学意义;治疗24周肝脏硬度下降,差异有统计学意义(P<0.05)。服药期间,患者免疫功能平稳,HIV-1 RNA均在检测下限。结论:对于AIDS合并代偿期肝硬化患者,唐草片具有良好的安全性,对肝脏具有一定保护作用。Objective:To observe the clinical efficacy of Tang Herb in the treatment of AIDS patients with compensated cirrhosis.Methods:A self-control study was conducted.Nineteen AIDS patients with cirrhosis after hepatitis B virus(HBV)and hepatitis C virus(HCV)infection were enrolled.Blood routine examination,liver and kidney function,five items of liver fibrosis,liver stiffness,immune cell function and HIV-1 RNA were measured at baseline,12 weeks and 24 weeks after treatment.Results:Compared with baseline,WBC,Hgb and PLT increased at 12 and 24 weeks after treatment,and the difference was not statistically significant.At 24 weeks after treatment,Alb increased,ALT and AST decreased,and the differences were statistically significant(P<0.05,P<0.01);The levels of direct TBil,DBil and Cr decreased,and the levels of Glb,PA and CHE increased,but the differences were not statistically significant(P>0.05);PIIIP decreased at 12 and 24 weeks of treatment,and the difference was statistically significant Significant(P<0.01);HA,LN,CⅣdecreased in different degrees,the difference was not statistically significant;24 weeks of treatment FIB decreased,the difference was statistically significant(P<0.05).During the medication,the patient's immune function was stable,and the HIV-1 RNA was at the lower limit of detection.Conclusion:For AIDS patients with compensated cirrhosis,Tang Herb has good safety and a certain protective effect on the liver.

关 键 词：唐草片 艾滋病 合并感染 代偿期肝硬化 

分 类 号：R575.2[医药卫生—消化系统]