多发性骨髓瘤患者来源间充质干细胞的最新研究进展  

The Latest Research Progress of Mesenchymal Stem Cells Derived from Multiple Myeloma Patients--Review

作　　者：凌小穗 何海萍 张丽华 李凡 LING Xiao-Sui;HE Hai-Ping;ZHANG Li-Hua;LI Fan(The Affiliated Hospital of Kunming University of Science and Technology;Department of Hematology,the First People′s Hospital of Yunnan Province,Kunming 650032,Yunnan Province,China)

机构地区：[1]昆明理工大学附属医院 [2]云南省第一人民医院血液科,云南昆明650032

出　　处：《中国实验血液学杂志》2023年第4期1233-1236,共4页Journal of Experimental Hematology

基　　金：国家自然科学基金(81760028);云南省临床医学中心开放课题(2019LCZXKF-XY09);云南省基础研究计划(昆医联合专项)(2018FE001)(-129);云南省医学学科带头人(D-2018017)。

摘　　要：多发性骨髓瘤(MM)是一种浆细胞恶性增殖性疾病,骨髓间充质干细胞(MSC)在MM的疾病进展过程中发挥着重要作用。与正常供者来源MSC(ND-MSC)相比,MM来源MSC(MM-MSC)表现出基因、信号通路、蛋白质表达水平和自身分泌细胞因子的异常,且其外泌体与骨髓微环境相互影响,以上原因可导致MM细胞增殖、化疗耐药、MM-MSC成骨分化障碍,并影响MM患者的免疫调节能力。为进一步了解MM的发病机理及相关影响因素,本文针对MM-MSC的最新研究进展作一综述。Multiple myeloma(MM)is a malignant proliferative disease of plasma cells.Bone marrow mesenchymal stem cells(MSC)play an important role in the progression of MM.Compared with normal donor derived MSC(NDMSC),MM patients derived MSC(MM-MSC)exhibit abnormalities in genes,signaling pathways,protein expression levels and cytokines secreted by themselves.Moreover,the exosomes of MM-MSC can interact with the bone marrow microenvironment.The above reasons can lead to MM cell proliferation,chemoresistance,impaired osteogenic differentiation of MM-MSC,and affect the immunomodulatory capacity of MM patients.In order to further understand the pathogenesis and related influencing factors of MM,this paper reviews the latest research progress of MM-MSC.

关 键 词：多发性骨髓瘤 间充质干细胞 信号通路 细胞因子 骨髓微环境 

分 类 号：R733.3[医药卫生—肿瘤]