纳米Ag@TiO_(2)、Fe@TiO_(2)和Zn@TiO_(2)的抑菌活性比较  

Comparative Research on Antibacterial Activity of Nano-Ag@TiO_(2),Fe@TiO_(2) and Zn@TiO_(2)

作　　者：龙威 陈志龙 刘穗汕 LONG Wei;CHEN Zhilong;LIU Suishan(College of Chemistry,Guangdong University of Petrochemical Technology,Maoming 525000,China)

机构地区：[1]广东石油化工学院化学学院,广东茂名525000

出　　处：《食品与生物技术学报》2023年第6期84-94,共11页Journal of Food Science and Biotechnology

基　　金：2021年度广东省大学生创新创业训练计划项目(73321098);茂名市科技计划项目(2021624,2019395);广东石油化工学院人才引进启动基金项目(2018rc50)。

摘　　要：探索常见金属离子掺杂对抑菌片的抑菌性能的影响,为新型纳米TiO_(2)抑菌片的制备与改善提供依据。选择固定质量分数的Ag+、Zn2+和Fe3+掺杂TiO_(2),通过抑菌圈、最小抑菌质量浓度(MIC)与最小杀菌质量浓度(MBC)综合评价其抑菌性能,对微观结构进行表征分析,探讨抑菌性能差异的原因。结果表明:抑菌性能大小顺序为Ag@TiO_(2)>Zn@TiO_(2)>Fe@TiO_(2),Zn@TiO_(2)的抑菌活性较好但抑菌稳定性差。Ag@TiO_(2)对大肠杆菌和金黄色葡萄球菌的MIC、MBC均是10、20 mg/L,Zn@TiO_(2)对大肠杆菌和金黄色葡萄球菌的MIC、MBC均是30、50 mg/L。表征发现抑菌活性强弱主要归因于纳米TiO_(2)表面与金属离子共同产生的活性位点数量及稳定性,与孔结构或表面官能团的关联不大。This study aimed to investigate the antibacterial properties effect of common metal ions doping on antibacterial tablets,providing a technical basis for the preparation and improvement of novel nano-TiO_(2) antibacterial tablets.The fixed mass fractions of Ag+,Zn2+and Fe3+doped on TiO_(2) antibacterial tableTSwere selected for comparative research,and the antibacterial properties were in-depth evaluated by antibacterial circle,minimum inhibitory concentration(MIC)and minimum bactericidal concentration(MBC)methods.The microscopic structure was characterized and analyzed to investigate the reasons for the differences in antibacterial properties.The resulTSshowed that the order of antibacterial activity was Ag@TiO_(2)>Zn@TiO_(2)>Fe@TiO_(2).Zn@TiO_(2) had higher antibacterial activity but poorer antibacterial stability.The MIC and MBC of Ag@TiO_(2) for Escherichia coli and Staphylococcus aureus were 10 mg/L and 20 mg/L,while those of Zn@TiO_(2) were 30 mg/L and 50 mg/L,respectively.Characterization revealed that the antibacterial activity was mainly attributed to the number and stability of active sites produced by the interaction between thenano-TiO_(2) surface and metal ions,and it was not closely related to the pore structure or surface functional groups.

关 键 词：TiO_(2) 抑菌活性 最小抑菌质量浓度 金属掺杂 最小杀菌质量浓度 

分 类 号：Q93[生物学—微生物学]