猪心房间隔穿刺的一种创新方法  

An innovative way of atrial septal puncture in swine

作　　者：杨力凡 潘文志 张蕾 张晓春 李明飞 龙愉良 管丽华 周达新 葛均波[2,3,4] YANG Li-fan;PAN Wen-zhi;ZHANG Lei;ZHANG Xiao-chun;LI Ming-fei;LONG Yu-liang;GUAN Li-hua;ZHOU Da-xin;GE Jun-bo(Department of Cardiology,Shanghai Xuhui District Central Hospital,Shanghai 200031,China;Department of Cardiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Shanghai Institute of Cardiovascular Diseases,Shanghai 200032,China;National Clinical Research Center for Interventional Medicine,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院徐汇医院心内科,上海200031 [2]复旦大学附属中山医院心内科,上海200032 [3]上海市心血管病研究所,上海200032 [4]国家放射与治疗临床医学研究中心,上海200032

出　　处：《复旦学报（医学版）》2023年第4期586-589,共4页Fudan University Journal of Medical Sciences

摘　　要：目的通过对猪心房间隔穿刺(atrial septum puncture,ASP)方法的改善,使操作更方便,心脏穿孔或心包积液的发生率更低,ASP更安全有效。方法在心腔内超声心动图(intra-cardiac echocardiography,ICE)引导下,使用0.014英寸SION导丝的尾端对28只约克夏白猪进行ASP。应用SPSS 22.0统计软件计算肺血流/全身血流平均值及平均ASP时间。术后4周观察房间隔穿刺孔闭合情况。结果成功对28只约克夏白猪进行ASP,超声心动图提示房间隔有左向右分流,无并发症发生。平均Qp/Qs为1.3±0.2(中位数1.3,95%CI:1.3~1.4),ASP平均用时(40.6±7.3)s(中位数41.0 s,95%CI:37.8~43.3 s)。手术4周后,28只猪的房间隔穿刺孔均内皮化导致闭合。结论在ICE引导下,使用0.014英寸SION导丝的尾端对约克夏白猪进行ASP安全且有效。Objective Improvement in the way of atrial septum puncture(ASP)in order to operate more conveniently,decrease complications and make ASP more safe and effective.Methods ASP was performed in 28 Yorkshire swines under intra-cardiac echocardiography(ICE)guidance with the end of a SION guidewire of 0.014 inch.Statistical analyses of average pulmonary/systemic blood flow and average ASP time were performed using SPSS 22.0.We observed the closure of ASP 4 weeks after surgery.Results ASP was successfully performed in 28 Yorkshire swines without complications.Ultrasound cardiography showed left to right shunt through atrial septum after ASP.The average Qp/Qs ratio was 1.3±0.2(median 1.3,95%CI:1.3-1.4).The average ASP time was(40.6±7.3)seconds(median 41 seconds,95%CI 37.8-43.3 seconds).Four weeks after surgery,the ASP holes in 28 swines were endothelialized and closed.Conclusion It is safe and efficient for ASP using the end of 0.014 inch SION guidewire under ICE guidance in Yorkshire swines.

关 键 词：房间隔穿刺(ASP) SION导丝 心腔内超声心动图(ICE) 猪 

分 类 号：R-332[医药卫生] R541