胶质淋巴转运MRI研究进展  

Research progresses of MRI in glymphatic transport

作　　者：陈心怡 卢艳丽[2] 桂千 王琳辉[1] CHEN Xinyi;LU Yanli;GUI Qian;WANG Linhui(Department of Physiology and Neurobiology,School of Biology&Basic Medical Sciences,Suzhou Medical College of Soochow University,Suzhou 215123,China;Department of Radiology,Suzhou Hospital Affiliated to Nanjing Medical University,Suzhou 215002,China;Department of Neurology,Suzhou Hospital Affiliated to Nanjing Medical University,Suzhou 215002,China)

机构地区：[1]苏州大学苏州医学院基础医学与生物科学学院生理学与神经生物学系,江苏苏州215123 [2]南京医科大学附属苏州医院(苏州市立医院)影像科,江苏苏州215002 [3]南京医科大学附属苏州医院(苏州市立医院)神经内科,江苏苏州215002

出　　处：《中国医学影像技术》2023年第8期1249-1252,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金面上项目(31871167)。

摘　　要：胶质淋巴系统(GS)是由星形胶质细胞终足上的水孔蛋白4(AQP4)介导的脑脊液和脑组织液交换流动系统,主要作用在于运输营养和清除脑内废物等。MRI能直接、迅速、无创显示脑脊液流动,可用于研究GS。本文就MRI研究GS进展进行综述。The glymphatic system(GS)has been described as one that facilitates the exchange between cerebrospinal fluid and interstitial fluid depending on the aquaporin-4(AQP4)water channels expressed in astrocytic end-feet,which mainly playing role in transporting nutrients and removing waste in the brain.MRI can directly,rapidly and noninvasively show the flow of cerebrospinal fluid,being used to study GS.The research progresses of MRI for GS were reviewed in this article.

关 键 词：胶质淋巴系统 磁共振成像 脑脊液 水孔蛋白质类 对比剂 

分 类 号：R741.02[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]