中西医结合临床治疗RAU的Meta分析与疗效评价  

Meta analysis and efficacy evaluation of integrated Chinese and Western medicine in the clinical treatment of RAU

作　　者：杨瑞[1] 杨馨 任诗琦 霍怡菲 李昀朴 张林祥 张宝平[2,3] Yang Rui;Yang Xin;Ren Shiqi;Huo Yifei;Li Yunpu;Zhang Linxiang;Zhang Baoping(Department of Prosthodontics,Stomatological Hospital of Lanzhou University,Lanzhou 730000,China;School of Stomatology,Lanzhou University,Lanzhou 730000,China;Key Laboratory of Dental-Maxillofacial Reconstruction and Biointelligent Manufacturing of Gansu Province,Lanzhou 730000,China)

机构地区：[1]兰州大学口腔医院口腔修复科,甘肃兰州730000 [2]兰州大学口腔医学院,甘肃兰州730000 [3]甘肃省牙颌面重建与生物智能制造重点实验室,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2023年第6期31-38,44,共9页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省自然科学基金资助项目(20JR10RA591)。

摘　　要：目的Meta分析中西医结合治疗复发性阿弗他溃疡(RAU),系统评估中西医治疗RAU的总有效率与复发率。方法计算机检索中国国家知识基础设施数据库、万方数据库、维普数据库、中国生物医学文献数据库、The Cochrane Library、PubMed、Web of Science数据库,收集自建库至2023年2月中西医结合治疗RAU的随机对照试验,采用Stata 15.1软件进行Meta分析。对照组仅采用维生素、漱口水或激素治疗,实验组在对照组治疗RAU的基础上结合中药汤剂、丸剂的中西医结合疗法治疗。比值比(OR)作为总有效率与复发率的合并效应量。结果共纳入26篇文献,包含2632例受试者。总有效率的异质性检验P=1.000,I 2=0.0%,显示异质性较小,故采用固定效应模型。合并效应量OR=4.96,95%CI:[3.83,6.43],表明中西医结合疗法有效率高于对照组;复发率的异质性检验P=1.000,I 2=0.0%,显示异质性较小,采用固定效应模型。合并效应量OR=0.3,95%CI:[0.25,0.46],表明中西医结合疗法复发率低于对照组。结论相比于西医单一治疗方式,中西医结合明显提高了RAU治疗的总有效率,降低了复发率。Objective To Meta-analyze the research in a recurrent aphthous ulcer(RAU)and to systematically evaluate the impact of recurrent Chinese and Western medicine on the total response rate and recurrence rate of RAU.Methods Chinese National Knowledge Infrastructure database,Wanfang database,VIP database,Chinese Biomedical Literature database,The Cochrane Library,PubMed and Web of Science database were searched via computer,and randomly controlled trials of integrated Chinese and Western medicine in the treatment of RAU were collected from the establishment of the databases to February 2023.Meta analysis was performed using Stata 15.1 software.The control group was only treated with vitamin,mouthwash or hormone,while the experimental group with traditional Chinese and Western medicine combined with herbal decoction and pills on the basis of RAU treatment in the control group.OR was used as the combined effect size to conduct a Meta-analysis of the total effective rate and recurrence rate of the included studies.Results A total of 26 programs were included,including 2632 subjects.The total effective rate(P=1.000,I 2=0.0%,OR=4.96,95%CI:[3.83,6.43])of the included studies showed that the combined treatment of Chinese and Western medicine was positively correlated with the total effective rate of RAU.The recurrence rate(P=1.000,I 2=0.0%,OR=0.3,95%CI:[0.25,0.46])showed that the combination of Chinese and Western medicine was negatively correlated with the recurrence rate of RAU.Both outcome indexes had a high homogeneity and low risk of bias.Subgroup analysis of treatment time and follow-up time showed no significant effect on the two outcome indexes.Conclusion Compared with western medicine monotherapy,combination of traditional Chinese and Western medicine can significantly improve the total effective rate of RAU treatment and reduce the recurrence rate.

关 键 词：中西医结合 复发性阿弗他溃疡 系统综述 

分 类 号：R781.5[医药卫生—口腔医学]