缺血性肝炎  

Ischemic hepatitis

作　　者：张瀚予 罗娟[1,2] 缪应雷 Han-Yu ZHANG;Juan LUO;Ying-Lei MIAO(Department of Gastroenterology,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,China;Yunnan Province Clinical Research Center for Digestive Diseases,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院消化内科,昆明650032 [2]云南省消化系统疾病临床医学研究中心,昆明650032

出　　处：《医学新知》2023年第4期295-302,共8页New Medicine

基　　金：国家自然科学基金面上项目(82170550)。

摘　　要：缺血性肝炎又称缺氧性肝炎、休克肝,是一种常在心脏、呼吸、循环衰竭基础上发生的肝脏急性缺血缺氧性损伤,以血清氨基转移酶急剧升高和小叶中央细胞坏死为特征的临床综合征,在重症监护病房中较多见。其发病机制复杂、早期识别困难、预后差、病死率高,目前尚无明确的诊断标准及特异性治疗方案。本文对缺血性肝炎的流行病学、病因、发病机制及诊疗进展进行概述,以期加深临床对该疾病的认知,促进早期识别与及时治疗,提高其诊疗水平。Ischemic hepatitis(IH),also known as hypoxic hepatitis(HH)or shock liver,is a clinical syndrome characterized by a rapid,significant rise in the plasma aminotransferase level and centrilobular liver cell necrosis.IH has a strong relationship with cardiac,respiratory and circulatory failure that all result in poor perfusion and oxygen delivery to the liver.It's not rare in intensive care units(ICU).The pathogenesis of IH is complex and early diagnosis is difficult.Meanwhile there are still no clear diagnostic criteria and specific treatment options for IH,which results in a poor prognosis and high mortality rate.This review provides an overview of the epidemiology,etiology,pathogenesis and the advance of current treatment of IH,in order to deepen the clinical knowledge of this disease,promote early recognition and timely treatment,and improve its diagnosis and treatment.

关 键 词：缺血性肝炎 缺氧性肝炎 发病机制 诊断 治疗 

分 类 号：R575.1[医药卫生—消化系统]