熊去氧胆酸治疗对妊娠期肝内胆汁淤积综合征患者的影响  

Effect of Ursodeoxycholic Acid Treatment on Patients with Intrahepatic Cholestasis Syndrome During Pregnancy

作　　者：刘勇战 林耀蕙 LIU Yong-zhan;LIN Yao-hui(Joint Support Force 989th Hospital,Henan Pingdingshan 467000)

机构地区：[1]联勤保障部队第989医院,河南平顶山467000

出　　处：《深圳中西医结合杂志》2023年第11期85-88,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨妊娠期肝内胆汁淤积综合征患者应用熊去氧胆酸后对肝功能及妊娠结局的影响。方法:选取2018年2月至2019年11月期间联勤保障部队第989医院收治的138例妊娠期肝内胆汁淤积综合征患者,随机数字表法将其分为对照组、观察组,各69例。对照组采取常规药物治疗,观察组在常规药物治疗的基础上联合应用熊去氧胆酸。比较两组患者肝功能水平的变化以及妊娠结局。结果:治疗后,两组患者谷草转氨酶(AST)、总胆汁酸(TBA)、总胆红素(TBIL)、谷丙转氨酶(ALT)等肝功能指标水平均低于治疗前,且观察组均低于对照组,差异具有统计学意义(P<0.05);观察组患者剖宫产、分娩大出血、新生儿窒息或窘迫、羊水污染的发生率均低于对照组,差异具有统计学意义(P<0.05);观察组患者终止妊娠时孕周长于对照组,观察组患者终止妊娠时新生儿体质量重于对照组,差异具有统计学意义(P<0.05)。结论:熊去氧胆酸对妊娠期肝内胆汁淤积综合征患者肝功能的改善效果较好,且联合用药后患者的妊娠结局优于常规治疗方案。Objective To investigate the effects of ursodeoxycholic acid on liver function and pregnancy outcomes in patients with intrahepatic cholestasis syndrome during pregnancy.Methods A total of 138 patients with intrahepatic cholestasis syndrome of pregnancy admitted to Joint Support Force 989th Hospital from February 2018 to November 2019 were selected and randomly divided into a control group and an observation group,with 69 cases in each group.The control group received conventional drug treatment,and the observation group received ursodeoxycholic acid combined with conventional drug treatment.The changes in liver function indexes and pregnancy outcomes were compared between the two groups.Results After treatment,the levels of liver function indicators such as aspartate transaminase(AST),total bile acid(TBA),total bilirubin(TBIL)and alanine transaminase(ALT)in the two groups were lower than those before treatment,and the observation group were lower than those in the control group,with a statistically significant difference(P<0.05);The incidence of cesarean section,postpartum hemorrhage,neonatal asphyxia or distress,and amniotic fluid contamination in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05);The gestational circumference of the observation group patients at the time of termination of pregnancy was longer than that of the control group,while the neonatal body mass of the observation group patients at the time of termination of pregnancy was heavier than that of the control group,with a statistically significant difference(P<0.05).Conclusion Ursodeoxycholic acid has a good effect on improving liver function in patients with intrahepatic cholestasis syndrome during pregnancy,and the combined medication has better pregnancy outcomes than conventional treatment regimens.

关 键 词：妊娠期肝内胆汁淤积综合征 熊去氧胆酸 妊娠结局 肝功能 

分 类 号：R575[医药卫生—消化系统]