错配修复蛋白表达缺失在子宫内膜癌中的临床病理意义  

Clinical and Pathological Significance of Expression Loss of Mismatch Repair Protein in Endometrial Cancer

作　　者：范晓慧 陈丽红 赵文丽[1] 眭文妍[1] 陈明铨 FAN Xiao-hui;CHEN Li-hong;ZHAO Wen-li;SUI Wen-yan;CHEN Ming-quan(Huizhou First Hospital,Guangdong Huizhou 516000)

机构地区：[1]惠州市第一人民医院,广东惠州516000

出　　处：《深圳中西医结合杂志》2023年第12期1-3,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：惠州市科学技术局项目(210406234572926)。

摘　　要：目的:探究错配修复(MMR)蛋白表达缺失在子宫内膜癌(EC)中的临床病理意义。方法:选取惠州市第一人民医院2019年3月至2022年12月收集的EC患者术后石蜡包埋子宫内膜组织标本50例,采用免疫组织化学检测法检测MMR蛋白表达,包含MLH1、MSH2、MSH6及PMS2,观察MMR蛋白表达缺失率,对不同年龄及EC病理特征的MMR蛋白表达缺失情况进行比较。结果:(1)50例EC患者MMR蛋白表达缺失发生率为36.00%。MMR蛋白MLH1、MSH2、PMS2、MSH6表达缺失率分别为22.00%、6.00%、30.00%、6.00%,其中单项缺失4例(8.00%),两项表达缺失14例(18.00%)。(2)≤50岁EC患者MMR蛋白缺失表达率(56.00%)高于>50岁EC患者(16.00%),差异具有统计学意义(P<0.05)。(3)不同细胞分化程度、肌层浸润程度及淋巴结转移情况患者MMR蛋白表达缺失情况比较,差异均无统计学意义(P>0.05)。结论:MMR蛋白在EC中表达缺失率较高,以PMS2表达缺失为主,且MMR蛋白表达缺失率在≤50岁EC患者中更高,故需重视对年轻女性EC早期筛查。Objective Exploring the clinical and pathological significance of mismatch repair(MMR)protein expression loss in endometrial cancer(EC).Methods Fifty postoperative paraffin embedded endometrial tissue samples from EC patients at Huizhou First Hospital from March 2019 to December 2022 were selected.Immunohistochemical detection was used to detect the expression of MMR protein,including MLH1,MSH2,MSH6,and PMS2.The expression loss rate of MMR protein was observed,and the expression loss of MMR protein was compared among different ages and EC pathological characteristics.Results(1)The incidence of MMR protein expression loss in 50 EC patients was 36.00%.The expression deletion rates of MMR protein MLH1,MSH2,PMS2,and MSH6 were 22.00%,6.00%,30.00%,and 6.00%,respectively.Among them,there were 4 cases of single deletion(8.00%)and 14 cases of two expression deletions(18.00%).(2)The expression rate of MMR protein deficiency in EC patients≤50 years old(56.00%)was higher than that in EC patients>50 years old(16.00%),and the difference was statistically significant(P<0.05).(3)There was no statistically significant difference in the expression of MMR protein among patients with different levels of cell differentiation,muscle infiltration,and lymph node metastasis(P>0.05).Conclusion The expression loss rate of MMR protein in EC is relatively high,with PMS2 expression loss being the main factor.Moreover,the expression loss rate of MMR protein is higher in EC patients≤50 years old.Therefore,it is necessary to pay attention to early screening for related heritability in young women.

关 键 词：子宫内膜癌 错配修复蛋白 蛋白表达缺失 林奇综合征 

分 类 号：R737.33[医药卫生—肿瘤]