GDF-15基因多态性、膳食与中心性肥胖的相关性研究  

A study of the correlation of GDF-15 gene polymorphism with diet and central obesity

作　　者：梁玉坚 王雪秀 覃丽冬 蔡建升 覃健[1,2,3,4] 张志勇[1,6,7] LIANG Yujian;WANG Xuexiu;QIN Lidong;CAI Jiansheng;QIN Jian;ZHANG Zhiyong(School of Public Health,Ministry of Education of China,Guangxi Medical University,Nanning 530021;Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases,Ministry of Education of China,Guangxi Medical University,Nanning 530021;Guangxi Key Laboratory of Environment and Health Research,Ministry of Education of China,Guangxi Medical University,Nanning 530021;Key Laboratory of Longevity and Aging Related Diseases,Ministry of Education of China,Guangxi Medical University,Nanning 530021;Key Laboratory of Tumor Immunology and Microenvironmental Regulation,Guilin Medical University,Guilin 541199,China;School of Public Health,Guilin Medical University,Guilin 541199,China;Guangxi key Laboratory of Environmental Exposomics and Entire Lifecycle Health,Guilin Medical University,Guilin 541199,China)

机构地区：[1]广西医科大学公共卫生学院,广西南宁530021 [2]广西医科大学广西高校高发疾病防治重点实验室,广西南宁530021 [3]广西医科大学广西环境与健康研究重点实验室,广西南宁530021 [4]广西医科大学中国教育部长寿与衰老相关疾病重点实验室,广西南宁530021 [5]桂林医学院肿瘤免疫学和微环境调控重点实验室,广西桂林541199 [6]桂林医学院公共卫生学院,广西桂林541199 [7]桂林医学院广西环境暴露组学与全生命周期健康研究重点实验室,广西桂林541199

出　　处：《华夏医学》2023年第3期1-7,共7页Acta Medicinae Sinica

基　　金：国家自然科学基金项目(81760577,81660528);广西科技重大专项项目(AA22096026);广西科技发展项目(AD17129003,AD18050005);广西自然科学基金创新研究团队项目(2019GXNSFGA245002)。

摘　　要：目的:探究GDF-15基因多态性与膳食因素的交互作用及其与中心性肥胖的关联。方法:采用Sequenom MassArray系统对GDF-15基因多态性分型。使用食物频率问卷(FFQ)法调查膳食摄入情况。应用Logistic回归分析SNP位点、膳食因素及两者间交互作用与中心性肥胖的关联。结果:Logistics回归分析显示,携带GDF-15基因rs1059519CG基因型人群患中心性肥胖的风险高于携带GDF-15基因rs1059519GG基因型人群,OR为1.986(95%CI:1.011~3.900,P<0.05)。饱和脂肪酸、多不饱和脂肪酸的中等摄入量与中心性肥胖的风险相关,OR分别为1.983(95%CI:1.139~3.451,P<0.05)和2.146(95%CI:1.238~3.719,P<0.05)。rs1059519CG基因型与饱和脂肪酸、多不饱和脂肪酸中等摄入量的交互作用会增加中心性肥胖的风险,OR分别为2.737(95%CI:1.241~4.536,P<0.05)和2.852(95%CI:1.540~5.281,P<0.05)。结论:GDF-15基因多态性、饱和脂肪酸、多不饱和脂肪酸摄入及两者间交互作用与中心性肥胖相关。Objective:To explore the role of GDF-15 gene polymorphism and dietary factors in central obesity,as well as the correlation between their interaction and central obesity.Methods:The Sequenom MassArray system was used to classify GDF-15 gene polymorphism.The Food Frequency Questionnaire(FFQ) method was used to investigate dietary intake.Logistic regression analysis was applied to investigate the association between SNP loci,dietary factors,and their interactions with central obesity.Results:Logistic regression analysis showed that individuals with the GDF-15 rs1059519CG genotype had a higher risk of central obesity than those with the GDF-15 rs1059519GG genotype,the odds ratio(OR) was 1.986(95% CI:1.011 ~3.900,P<0.05).The moderate intake of saturated fatty acids and polyunsaturated fatty acids was associated with the risk of central obesity,the OR was 1.983(95% CI:1.139~ 3.451,P<0.05) and 2.146(95% CI:1.238~3.719,P<0.05),respectively.The interaction between rs1059519CG genotype and the moderate intake of saturated fatty acids and polyunsaturated fatty acids increased the risk of central obesity,with the OR of 2.737(95% CI:1.241~4.536,P<0.05) and 2.852(95% CI:1.540~5.281,P<0.05),respectively.Conclusion:Polymorphism of GDF-15 gene,intake of saturated and polyunsaturated fatty acids,and their interactions are associated with central obesity.

关 键 词：GDF-15基因多态性 中心性肥胖 膳食脂肪酸 

分 类 号：R589.2[医药卫生—内分泌]