奥卡西平治疗对不同年龄段癫痫患者tHcy表达水平的差异分析  

作　　者：洪丽芳[1] 贾方增 赵肖君[1] 陈文斌[1] 刘俊[1] 张幸[1] 

机构地区：[1]浙江省台州市第二人民医院,317200

出　　处：《浙江临床医学》2023年第7期1017-1018,共2页Zhejiang Clinical Medical Journal

基　　金：浙江省台州市科技计划B类(1902ky99)。

摘　　要：目的探讨奥卡西平治疗不同年龄段癫痫患者血清总同型半胱氨酸(tHcy)水平差异。方法选择癫痫患者100例,根据年龄段分为儿童/青少年组(≤16岁)和成人组(>16岁),均服用奥卡西平进行治疗,于治疗前和6个月后检测血清tHcy值,比较两组血清tHcy水平的差异,并进行多因素分析评估风险因素。结果两组治疗前后血清tHcy水平差值和高血清tHcy(>15μmolol/L)比例差异有统计学意义(P<0.05)。Logistic回归分析显示,叶酸和维生素B12是奥卡西平治疗后血清tHcy水平升高的风险因素(P<0.05)。年龄不是血清tHcy水平升高的风险因素。结论儿童/青少年与成人服用奥卡西平治疗癫痫后血清tHcy水平升高程度不同,但年龄不是血清tHcy水平升高的风险因素。Objective To investigate the effect and difference of serum Total homocysteine(tHcy)levels in patients with epilepsy with different ages treated with oxcarbazepine.Methods 100 epilepsy patients were collected and divided into the children/adolescent group(≤16 years old)and the adult group(>16 years old)according to ages.They were treated with oxcarbazepine.Serum Hcy levels were detected at the beginning of treatment and after 6 months.Statistical analysis of the changes and differences in serum Hcy levels was done between the two groups,and multivariate analysis was done to evaluate risk factors.Results The difference in serum tHcy levels before and after the treatment between the two groups and the high serum tHcy(>15μmolol/L)ratio had statistical significance(P<0.05).Logistic regression analysis showed that folic acid and Vitamin B12 were risk factors for the increase of serum tHcy level after the treatment with oxcarbazepine(P<0.05).Age was not a risk factor for elevated serum tHcy levels.Conclusion Children/adolescents and adults have different levels of serum Hcy levels after taking oxcarbazepine for epilepsy treatment.But age was not a risk factor for elevated serum tHcy levels.

关 键 词：奥卡西平 癫痫 同型半胱氨酸 

分 类 号：R742.1[医药卫生—神经病学与精神病学]