Regulation of neural stem cell by bone morphogenetic protein (BMP) signaling during brain development  

作　　者：Yiming SUN Zhiheng XU 

机构地区：[1]The Key Laboratory of Molecular and Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Frontiers in Biology》2010年第5期380-385,共6页生物学前沿（英文版）

摘　　要：Neurogenesis is the process in which neurons are generated from neural stem/progenitor cells(NSCs/NPCs).It involves the proliferation and neuronal fate specification/differentiation of NSCs,as well as migration,maturation and functional integration of the neuronal progeny into neuronal network.NSCs exhibit the two essential properties of stem cells:self-renewal and multi-potency.Contrary to previous dogma that neurogenesis happens only during development,it is generally accepted now that neurogenesis can take place throughout life in mammalian brains.This raises a new therapeutic potential of applying stem cell therapy for stroke,neurodegenerative diseases and other diseases.However,the maintenance and differentiation of NSCs/NPCs are tightly controlled by the extremely intricate molecular networks.Uncovering the underlying mechanisms that drive the differentiation,migration and maturation of specific neuronal lineages for use in regenerative medicine is,therefore,crucial for the application of stem cell for clinical therapy as well as for providing insight into the mechanisms of human neurogenesis.Here,we focus on the role of bone morphogenetic protein(BMP)signaling in NSCs during mammalian brain development.

关 键 词：Bone morphogenetic protein(BMP) neural stem cell neural progenitor cell neural differentiation neuronal migration brain development collapsing response mediator protein 2(CRMP2) 

分 类 号：R74[医药卫生—神经病学与精神病学]