卵巢未成熟畸胎瘤术后肝转移成熟性畸胎瘤一例  

A Case of Mature Teratoma with Liver Metastasis after Surgery for Ovarian Immature Teratoma

作　　者：杨琳 郭红燕[1] YANG Lin;GUO Hong-yan(Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院妇产科,100191

出　　处：《国际妇产科学杂志》2023年第4期387-391,共5页Journal of International Obstetrics and Gynecology

摘　　要：卵巢未成熟畸胎瘤(ovarian immature teratoma)为好发于青春期女性的常见卵巢生殖细胞恶性肿瘤。治疗以手术切除为主,必要时需术后辅助化疗。本例患者为剖宫产术中发现左侧卵巢中分化未成熟畸胎瘤,术后予以博来霉素+依托泊苷+顺铂(BEP)方案化疗3个疗程后出现肝区畸胎瘤转移。二次肿物切除术后,病理结果提示成熟性畸胎瘤,结合病史考虑为生长性畸胎瘤综合征(growing teratoma syndrome,GTS)。追踪过程中肝区病灶有可疑反复,但逐渐消失。术后随访1年,患者未复发。在卵巢未成熟畸胎瘤的治疗过程中,GTS罕见,发病机制特殊,并易被误诊为卵巢未成熟畸胎瘤复发或进展。因此,了解GTS并在临床加以重视十分必要。Ovarian immature teratoma is a common ovarian germ cell malignant tumor that occurs in adolescent females.Surgical resection is the main treatment,and postoperative adjuvant chemotherapy is required if necessary.This case is an immature differentiated teratoma in the left ovary found during cesarean section.After 3 courses of chemotherapy with BEP regimen,the liver teratoma metastasis occurred.The pathological results after the second tumor resection suggest that mature teratoma is considered as growing teratoma syndrome(GTS).During the course of follow-up,the liver lesions were suspicious and reappeared,but gradually disappeared.Follow-up for 1 year showed no recurrence.During the treatment of ovarian immature teratoma,GTS is rare,has a special pathogenesis,and is easily misdiagnosed as recurrence or progression of ovarian immature teratoma.Therefore,it is necessary to understand GTS and pay attention to it in clinical practice.

关 键 词：卵巢未成熟畸胎瘤 畸胎瘤 卵巢肿瘤 肝转移 肿瘤转移 肝肿瘤 生长性畸胎瘤综合征 治疗 病例报告 

分 类 号：R737.31[医药卫生—肿瘤] R735.7[医药卫生—临床医学]