143例新型冠状病毒肺炎患者伴发抑郁焦虑症状的影响因素研究  

Influence factors for concomitant depressive anxiety symptoms in 143 patients with Corona Virus Disease 2019(COVID-19)

作　　者：杨洛宁 范玉兰 孙仕田[1] YANG Luoning;FAN Yulan;SUN Shitian(Linyi Mental Health Center,Linyi 276005,China)

机构地区：[1]临沂市精神卫生中心,山东临沂276005

出　　处：《精神医学杂志》2022年第6期620-624,共5页Journal of Psychiatry

基　　金：临沂市科技发展计划项目(编号:202120022)。

摘　　要：目的研究新型冠状病毒肺炎患者伴发抑郁焦虑症状的影响因素。方法选择新型冠状病毒肺炎患者143例,采用汉密尔顿抑郁量表(HAMA)、汉密尔顿抑郁量表(HAMD)分组,用t检验与卡方检验对抑郁、焦虑组和无抑郁、无焦虑组的性别、年龄、性格、婚姻状况、职业、受教育年限、居住地、家庭月收入、淋巴细胞数量、C反应蛋白、D-二聚体、血沉进行对比分析;采用二元Logistic回归分析新冠肺炎伴发抑郁焦虑影响因素。结果新型冠状病毒肺炎合并焦虑、合并抑郁发生率为22.38%、19.58%,焦虑组性格内向、无固定职业、家庭月收入<5000元和D-二聚体占比均高于无焦虑组(P<0.05)。抑郁组淋巴细胞数量、C反应蛋白、D-二聚体、性格内向、无固定职业、家庭月收入<5000元占比均高于无抑郁组(P<0.05)。回归分析结果显示,性格内向、D-二聚体升高是发生焦虑的危险因素(P<0.05);家庭月收入≥5000元、有固定职业是发生焦虑的保护因素(P<0.05)。性格为内向、D-二聚体、淋巴细胞数量、C反应蛋白是发生抑郁的危险因素(P<0.05);有固定职业、家庭月收入≥5000元是发生抑郁的保护因素(P<0.05)。结论新型冠状病毒肺炎伴发焦虑抑郁症状的风险因素是性格内向和D-二聚体、淋巴细胞数量、C反应蛋白升高,保护因素是高家庭收入及有固定职业。可以提前预测焦虑抑郁发生的可能性,提高治疗效果和改善恢复预后。Objective To explore the influence factors for concomitant depressive anxiety symptoms in patients with Corona Virus Disease 2019(COVID-19).Methods 143 patients with COVID-19 were selected and divided into two groups according to Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD).T-test and chi square test were used to compare genders,ages,characteristics,marital status,occupations,years of education,residences,monthly household incomes,lymphocyte numbers,C-reactive protein levels,D-dimer levels and erythrocyte sedimentation rates between depression,anxiety groups and non-depression,non-anxiety groups;binary logistic regression was used to analyze the influencing factors of depression and anxiety in patients with COVID-19.Results The incidence rates of anxiety and depression in patients with COVID-19 were 22.38%and 19.58%respectively.The anxiety group showed more introversion,higher D-dimer level,tended to have no fixed occupation and monthly household income<5000 yuan than non-anxiety group(P<0.05).The depression group showed more introversion and higher lymphocyte levels,higher C-reactive protein levels,higher D-dimer levels,tended to have no fixed occupation and monthly household income<5000 yuan than non-depression group(P<0.05).Regression analysis showed that introversion and elevated D-dimer were risk factors for anxiety(P<0.05),and monthly household income≥5000 yuan and fixed occupation were protective factors for anxiety(P<0.05).Introversion,elevated D-dimer,lymphocyte and C-reactive protein were risk factors for depression(P<0.05),and having a fixed occupation and monthly household income≥5000 yuan were protective factors for depression(P<0.05).Conclusion The risk factors for COVID-19 with anxiety and depression symptoms are introversion,elevated D-dimer,lymphocyte number and C-reactive protein,and the protective factors are higher family incomes and fixed occupation.To predict the possibilities of anxiety and depression in advance may help improve the treatment effect and recovery progn

关 键 词：新型冠状病毒肺炎 焦虑 抑郁 二元Logistic回归分析 

分 类 号：R749.4[医药卫生—神经病学与精神病学]