睾丸混合性生殖细胞肿瘤11例诊治报告  

Diagnosis and treatment of testicular mixed germ cell tumor:a report of 11 cases

作　　者：单祖卷 王锦锐 余闫宏[1] SHAN Zujuan;WANG Jinrui;YU Yanhong(Department of Urology,The First People’s Hospital of Yunnan Province Affiliated to Kunming University of Science and Technology,Kunming 650100,China)

机构地区：[1]昆明理工大学附属云南省第一人民医院泌尿外科,云南昆明650100

出　　处：《现代泌尿外科杂志》2023年第8期674-678,共5页Journal of Modern Urology

基　　金：云南省“高层次人才培养计划”名医专项(YNWR-MY-2020-031)。

摘　　要：目的 结合11例睾丸混合性生殖细胞肿瘤(MGCT)患者的临床资料探讨MGCT的诊治。方法 回顾性分析我科2017年3月-2022年8月收治的经术后病理证实为MGCT的11例患者的临床资料,总结其临床特点、治疗方式及治疗效果,并结合相关文献和指南进行讨论。结果 MGCT患者占我科同一时期收治睾丸肿瘤(TC)的18.3%(11/60),占生殖细胞肿瘤(GCT)的21.2%(11/52)。11例MGCT病例均为单侧病变,左侧7例,右侧4例,左右侧之比1.75∶1。发病年龄21~52岁,平均(29.8±8.7)岁。所有病例均接受单侧睾丸根治性切除术(RO),7例接受腹膜后淋巴结清扫术(RPLND)(其中1例为机器人辅助下RPLND),6例接受术后化疗,1例行术后放疗。随访2~66月,平均随访(31.9±20.9)月,随访期内所有病例未见复发转移。结论 MGCT是一种临床相对少见的恶性肿瘤,预后较精原细胞瘤(SGCT)差,规范诊治并兼顾各病理类型的特殊性能获得较长的生存。Objective To explore the diagnosis and treatment of mixed germ cell tumor(MGCT).Methods Clinical data of 11 confirmed MGCT cases treated in our hospital during Mar.2017 and Aug.2022 were retrospectively analyzed.The clinical characteristics,treatment methods and therapeutic effects were analyzed.The relevant literature and guidelines were discussed.Results MGCT cases accounted for 18.3%(11/60)of testicular cancer(TC)cases and 21.2%(11/52)of germ cell tumor(GCT)cases treated in our department during the same period.All 11 MGCT cases had unilateral lesions,which were on the left side in 7 cases,and on the right side in 4 cases,with a ratio of left to right side of 1.75∶1.The age of onset ranged from 21 to 52 years,average(29.8±8.7)years.All cases received unilateral radical orchiectomy(RO),7 received retroperitoneal lymph node dissection(RPLND)(1 robotic RPLND),6 received postoperative chemotherapy,and 1 received postoperative radiotherapy.During the follow-up of 2 to 66[average(31.9±20.9)months],no recurrence or metastasis were observed.Conclusion MGCT is a relatively rare malignant tumor in clinical practice,with worse prognosis than seminoma germ cell tumor(SGCT).Standardized diagnosis and treatment based on the special characteristics of each pathological type can improve the survival.

关 键 词：睾丸肿瘤 腹膜后淋巴结清扫 睾丸根治性切除术 化疗 

分 类 号：R737.21[医药卫生—肿瘤]