新辅助化学治疗联合宫颈癌根治术治疗宫颈癌的临床疗效观察  

Clinical observation of neoadjuvant chemotherapy combined with radical resection of cervical cancer in the treatment of cervical cancer

作　　者：黄敏 陶珍桂 彭琼琳 HUANG Min;TAO Zhen-gui;PENG Qiong-lin(Obstetrics and Gynecology Department,Egang Hospital,Ezhou 436000,China)

机构地区：[1]鄂州市鄂钢医院妇产科,436000

出　　处：《中国现代药物应用》2023年第15期20-24,共5页Chinese Journal of Modern Drug Application

摘　　要：目的浅析宫颈癌开展新辅助化学治疗(NACT)联合宫颈癌根治术治疗的临床效果。方法60例宫颈癌患者作为研究对象,按照电脑盲选法分为参照组与干预组,每组30例。干预组实施NACT联合宫颈癌根治术治疗,参照组则实施宫颈癌根治术治疗。比较两组临床治疗效果、不良反应发生情况、疾病复发率、免疫功能指标水平、生活质量综合评定量表(GQOLI)和焦虑自评量表(SAS)评分。结果干预组治疗总有效率为90.00%,高于参照组的66.67%,差异具有统计学意义(P<0.05)。两组肝损害、神经毒性反应、血小板减少、中心粒细胞减少、胃肠道反应发生率对比差异无统计学意义(P>0.05)。干预组疾病复发率6.67%低于参照组的26.67%,差异具有统计学意义(P<0.05)。干预组CD3^(+)(70.53±5.67)%、CD4^(+)(40.86±5.64)%、CD4^(+)/CD8^(+)(1.84±0.14)均高于参照组的(64.84±5.83)%、(37.74±5.87)%、(1.34±0.11),CD8^(+)(24.33±3.56)%低于参照组的(26.53±3.37)%,差异具有统计学意义(P<0.05)。治疗前,两组SAS、GQOLI评分比较差异无统计学意义(P>0.05);治疗后,干预组SAS评分(37.50±4.81)分低于参照组的(49.78±4.21)分,GQOLI评分(85.51±5.68)分高于参照组的(73.62±6.19)分,差异具有统计学意义(P<0.05)。结论宫颈癌开展NACT联合宫颈癌根治术治疗效果显著,能够有效提升临床疗效,保障治疗安全,降低疾病复发率,改善免疫功能,提高生活质量,缓解负面情绪,值得借鉴与应用。Objective To analyze the clinical effect of neoadjuvant chemotherapy(NACT)combined with radical resection of cervical cancer in the treatment of cervical cancer.Methods A total of 60 patients with cervical cancer were divided into reference group and intervention group according to computer blind selection method,with 30 cases in each group.The intervention group was treated with NACT and radical resection of cervical cancer,and the reference group was treated with radical resection of cervical cancer.The clinical effect,occurrence of adverse reactions,disease recurrence rate,immune function index level,Generic Quality of Life Inventory(GQOLI)and Self-Rating Anxiety Scale(SAS)scores were compared between the two groups.Results The total effective rate of 90.00%in the intervention group was higher than that of 66.67%in the reference group,and the difference was statistically significant(P<0.05).There was no statistically significant difference between the two groups in terms of incidence of liver damage,neurotoxic reaction,thrombocytopenia,neutropenia and gastrointestinal reaction(P>0.05).The disease recurrence rate of the intervention group was 6.67%,which was lower than that of 26.67%of the reference group,and the difference was statistically significant(P<0.05).CD3^(+)of(70.53±5.67)%,CD4^(+)of(40.86±5.64)%and CD4^(+)/CD8^(+)of(1.84±0.14)in the intervention group were higher than those of(64.84±5.83)%,(37.74±5.87)%and(1.34±0.11)in the reference group;CD8^(+)of(24.33±3.56)%in the intervention group was lower than that of(26.53±3.37)%in the reference group;the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in SAS and GQOLI scores between the two groups(P>0.05).After treatment,SAS score of(37.50±4.81)points in the intervention group was lower than that of(49.78±4.21)points in the reference group,and GQOLI score of(85.51±5.68)points was higher than that of(73.62±6.19)points in the reference group.The differences were statistically sig

关 键 词：宫颈癌根治术 新辅助化学治疗 宫颈癌 复发率 

分 类 号：R737.33[医药卫生—肿瘤]