血清IL-32 sRAGE及NLR与多发性骨髓瘤合并肾损伤的相关性分析  

Correlation Analysis of Serum IL-32 sRAGE and NLR with Multiple Myeloma Complicated with Renal Injury

作　　者：姜铭[1] 徐娟[1] 丁林林 贲海祥 尹红[2] JIANG Ming;XU Juan;DING Linlin(Rugao People's Hospital,Jiangsu Rugao 226500,China)

机构地区：[1]江苏省如皋市人民医院,江苏如皋226500 [2]南通大学附属医院血液病研究室,江苏南通226000

出　　处：《河北医学》2023年第8期1279-1283,共5页Hebei Medicine

基　　金：江苏省南通市卫生健康委员会科研课题项目,(编号:QNZ2022065)。

摘　　要：目的:探讨血清白细胞介素-32(IL-32)、可溶性晚期糖基化终末产物受体(sRAGE)及中性粒细胞/淋巴细胞比值(NLR)与多发性骨髓瘤(MM)合并肾损伤的相关性分析。方法:选取2020年6月至2022年6月如皋市人民医院诊治的82例MM患者作为观察组,并根据患者肾功能情况分为肾损伤组(n=27)和非肾损伤组(n=55),同期选取41例健康体检者设立为健康对照组。对比IL-32、sRAGE、NLR水平;采用二元Logistic回归分析IL-32、sRAGE、NLR对MM患者并发肾损伤的影响;采用ROC曲线分析IL-32、sRAGE、NLR预测MM患者并发肾损伤的AUC值、敏感度、特异度。结果:观察组的IL-32、NLR均高于健康对照组,而sRAGE低于健康对照组(P<0.05)。肾损伤组的IL-32、NLR均高于非肾损伤组,而sRAGE低于非肾损伤组(P<0.05)。Logistic回归分析显示,IL-32、NLR水平升高和sRAGE水平下降是影响MM患者并发肾损伤的危险因素(P<0.05)。ROC曲线分析显示,血清IL-32、sRAGE、NLR预测MM患者并发肾损伤的AUC值分别为(0.761、0.765、0.802,P<0.05)。结论:血清IL-32、sRAGE、NLR表达水平会随MM患者并发肾损伤而升高。Objective:To investigate the correlation between serum interleukin-32(IL-32),soluble advanced glycation end-product receptor(sRAGE)and neutrophil/lymphocyte ratio(NLR)and multiple myeloma complicated with kidney injury.Methods:A total of 82 MM patients diagnosed and treated in Rugao People's Hospital from June 2020 to June 2022 were selected as the observation group,and were divided into renal injury group(n=27)and non-renal injury group(n=55)according to renal function,and 41 healthy physical examination patients were selected as the healthy control group during the same period.IL-32,sRAGE and NLR levels were compared.Binary Logistic regression was used to analyze the effects of IL-32,sRAGE and NLR on kidney injury in MM patients.ROC curve model was used to analyze the AUC value,sensitivity and specificity of IL-32,sRAGE and NLR in predicting kidney injury in MM patients.Results:IL-32 and NLR in observation group were higher than those in control group,while sRAGE was lower than those in control group(P<0.05).IL-32 and NLR in renal injury group were higher than those in control group,while sRAGE was lower(P<0.05).Logistic regression model analysis showed that increased IL-32,increased NLR and decreased sRAGE levels were risk factors for kidney injury in multiple myeloma patients(P<0.05).ROC curve analysis showed that the AUC values of serum IL-32,sRAGE and NLR in predicting kidney injury in multiple myeloma patients were 0.761,0.765 and 0.802,P<0.05.Conclusion:Serum IL-32,sRAGE,and NLR expression levels increased with kidney injury in MM patients.

关 键 词：白细胞介素-32 可溶性晚期糖基化终末产物受体 中性粒细胞/淋巴细胞比值 多发性骨髓瘤 肾损伤 

分 类 号：R733.3[医药卫生—肿瘤] R692[医药卫生—临床医学]