浓缩生长因子联合Biooss骨替代材料应用于即刻种植下颌后牙区骨缺失治疗的价值  

Value of Concentrated Growth Factors Combined with Biooss Bone Substitute Materials for the Treatment of Bone Loss in Mandibular Posterior Region with Immediate Implantation

作　　者：张宏波 孙传锋 张洋 ZHANG Hongbo;SUN Chuanfeng;ZHANG Yang(Lu'an People's Hospital,Anhui Lu'an 237005,China)

机构地区：[1]安徽医科大学附属六安医院口腔科,安徽六安237005

出　　处：《河北医学》2023年第8期1318-1324,共7页Hebei Medicine

基　　金：2020年度安徽省自然科学基金项目,(编号:2008085MC102)。

摘　　要：目的:探究浓缩生长因子(CGF)联合Biooss骨替代材料应用于即刻种植下颌后牙区骨缺失治疗的价值。方法:回顾性选取2019年6月至2022年6月于我院进行下颌后牙区即刻种植骨缺失患者101例,根据治疗方案的差异将患者分组:对照组51例,观察组50例,对照组采用Biooss骨替代材料治疗,观察组联用Biooss骨替代材料和浓缩生长因子,治疗后6个月对患者进行电话及门诊随访,比较两组患者水平及垂直植骨、成骨厚度及骨再生效果;根据患者术后稳定系数(ISQ)的变化对患者临床疗效进行评估,比较两组患者术后即刻、术后3个月、术后6个月的骨厚度、骨密度及骨宽度水平;对患者术后咀嚼功能恢复程度、牙龈乳头附着高度及整体性牙齿美观程度指标测算值进行比较。随访期结束时,收集患者的治疗满意度评价,并比较组间差异。结果:在水平及垂直方向,观察组再生骨效果(94.00%,92.00%)均优于对照组(90.19%,86.27%)。对照组患者ISQ均值呈现先下降后上升趋势,术后1周时患者的ISQ评分最低;观察组ISQ均值呈现逐步上升趋势。两组间在术后1周及术后4周时的ISQ均值比较存在统计学差异,观察组均值高于对照组(P<0.05),但两组在术后即刻、术后8周的ISQ均值比较差异无统计学意义(P>0.05)。两组术后即刻骨厚度、骨宽度及骨密度值处于同等水平,具有可比性(P>0.05);术后3个月及术后6个月两组患者的骨厚度、骨宽度及骨密度值比较存在统计学差异,观察组高于对照组(P<0.05)。与对照组相比较,观察组患者术后咀嚼功能恢复程度、牙龈乳头附着高度及整体性牙齿美观程度指标测算值均升高(P<0.05)。观察组的治疗满意度为96.00%,高于对照组满意率(84.31%),差异存在统计学意义(P<0.05)。结论:在对下颌后牙区骨缺失患者进行即刻种植时采用浓缩生长因子(CGF)联合Biooss骨替代材料可以提高患者满意度和骨再生效�Objective:To study the application value of concentrated growth factor(CGF)and Biooss bone substitute materials in mandibular implants.Methods:A total of 101 patients with immediate implant bone loss in mandibular posterior area in our hospital from June 2019 to June 2022 were retrospectively selected,and the patients were grouped according to differences in treatment regimen:51 in observation group and 50 in control group,The control group was treated with the Biooss bone substitute material,the observation group was given concentrated growth factors on the basis of the control group.The patients were followed up by telephone and outpatient clinic 6 months after the treatment to compare the horizontal and vertical bone grafting,bone thickness and bone regeneration effects between the two groups;the clinical efficacy of the patients was evaluated according to the changes in the postoperative stability coefficients(ISQ),and the levels of bone thickness,bone density,and bone width were compared between the two groups at the immediate postoperative stage,at 3 months after the surgery and at 6 months after the surgery;and the patients were compared with respect to the degree of recovery of the postoperative masticatory function,the height of gingival papilla attachment and overall dental esthetic degree index measurements.The measured values of the patients'postoperative masticatory function recovery,gingival papilla attachment height,and overall dental esthetics were compared.At the end of the follow-up period,patients'satisfaction with the treatment was collected and the differences between groups were compared.Results:The effect of bone regeneration in the horizontal and vertical directions(94.00%,92.00%)was better than that of the control group(90.19%,86.27%).The ISQ mean of patients in control group decreased first and then increased,with the lowest ISQ score of the patients,and the ISQ mean of observation group showed an increasing trend.The ISQ mean was different between both groups at 1 week and 4 weeks after

关 键 词：浓缩生长因子 Biooss 即刻种植 骨缺失 骨再生 

分 类 号：R783.6[医药卫生—口腔医学]