Phellinus igniarius ameliorates renal aging in a rat model of focal and segmental glomerulosclerosis  

作　　者：Zhou-Ting Wang Yue-Wen Tang Feng Wan Ru-Chun Yang Yan Guo Jie Zheng You-Gui Li Wei-Ming He 

机构地区：[1]School of Life Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,People’s Republic of China [2]Department of Nephrology(Key Laboratory of Kidney Disease Prevention and Control Technology,Zhejiang Province),Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou 310007,People’s Republic of China [3]Institute of Sericultural and Tea,Zhejiang Academy of Agricultural Sciences,Hangzhou 310021,People’s Republic of China

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2023年第8期359-368,共10页亚太热带生物医学杂志（英文版）

基　　金：supported by the Public Welfare Technology Application Research Program of Zhejiang Province (LGC21H290002);Key Projects of Zhejiang Administration of Traditional Chinese Medicine (2020ZZ016).

摘　　要：Objective:To comparatively investigate the ameliorative effect of Phellinus igniarius(P.igniarius)on renal aging in a rat model of focal and segmental glomerulosclerosis(FSGS).Methods:The FSGS model was established in rats by uninephrectomy combined with tail vein injection of doxorubicin.The FSGS rats were randomly divided into the model group,the P.igniarius decoction group,the P.igniarius polysaccharides group,and the P.igniarius polyphenols group.Molecular indicators of cell senescence,renal function indexes,and podocyte injury markers were tested after ten weeks of intragastric administration.Besides,the pathological renal lesions and the ultrastructural changes were observed.Results:FSGS developed in the model group within ten weeks and showed segmental glomerular scarring and renal aging.Following the 10-week intervention,24 h proteinuria,serum creatinine,blood urea nitrogen,P16^(INK4α),thrombospondin-1,and transforming growth factor-β1 were decreased in each treatment group,whereas albumin,erythropoietin,nephrin,and podocin were increased;the pathological renal injury was alleviated,and the number of senescent cells was reduced,especially in rats treated with P.igniarius decoction.Conclusions:P.igniarius ameliorates renal aging and renal injury in the FSGS rat model.Compared with the effective constituents(polysaccharides and polyphenols),P.igniarius decoction has a better curative effect,which is expected to provide a new therapeutic idea for FSGS.

关 键 词：Phellinus igniarius Polysaccharides POLYPHENOLS FSGS Renal aging RAT Renal injury 

分 类 号：R285.5[医药卫生—中药学]