乳腺癌疫苗研究进展  

Research progress in vaccine for breast cancer

作　　者：李梦茜 张克兢[1] 夏凡 LI Mengxi;ZHANG Kejing;XIA Fan(Department of General Surgery,Xiangya Hospital,Central South University,Clinical Research Center for Breast Cancer in Hunan Province,Changsha 410008,Hunan,China)

机构地区：[1]中南大学湘雅医院普外科(乳腺科),湖南省乳腺癌防治临床医学研究中心,湖南410008

出　　处：《中国临床药理学与治疗学》2023年第8期918-925,共8页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：湖南省自然科学基金-青年基金项目(S2020JJQNJJ0014);北京医卫健康公益基金会-医学科学研究基金(YWJKJJHKYJJB17465)。

摘　　要：2020年,乳腺癌占全球所有新发癌症病例的11.7%,其次是肺癌,乳腺癌已成为全球发病率第一的恶性肿瘤,严重威胁女性健康。随着治疗手段的不断丰富,乳腺癌患者的预后得到了极大的改善。疫苗的出现,是人类医学史上的重大进步,在肿瘤治疗领域,对于特定诱因致病的肿瘤,如人乳头瘤病毒(HPV)感染导致的宫颈癌,接种预防型疫苗已得到普及。目前乳腺癌的致病因素仍未明确,开发针对于乳腺癌的预防型疫苗难度较大。近些年来,在乳腺癌治疗领域,涌现出多种治疗型疫苗。在患者接受综合治疗结束后,利用疫苗刺激机体免疫系统,识别肿瘤细胞特异抗原并杀伤,从而尽可能降低乳腺癌的复发机率。这些疫苗,目前多是针对于恶性程度更高的三阴性乳腺癌以及人表皮生长因子受体2(HER2)阳性乳腺癌,本文将着重梳理几款此类疫苗的研究进展。Breast cancer was the most commonly diagnosed cancer,with an estimated 2.3 million new cases(11.7%),followed by lung(11.4%)in 2020.Breast cancer ranks first among malignant tumors in the world,seriously threatening women's health.Due to continuously enrichment of treatment methods for breast cancer,patients'prognosis have been greatly improved.The emergence of vaccines is an important treatment method to promote the development of human health.For cancer therapy,preventive vaccines have been popularized for kinds of tumor with specific incentives,such as cervical cancer caused by HPV infection.At present,the causative factors of breast cancer are still unclear,and it is still difficult to develop preventive vaccines against breast cancer.In recent years,a variety of therapeutic vaccines have emerged in the field of breast cancer treatment.When patient completed comprehensive treatment,vaccine is used to stimulate body immune system to recognize tumor cell-specific antigens,thereby reducing the recurrence rate as much as possible.Most of these vaccines are currently aimed at more malignant triple-negative breast cancer and HER2-positive breast cancer.This article will focus on the research progress of several therappeutic vaccines.

关 键 词：乳腺癌 疫苗 

分 类 号：R737.9[医药卫生—肿瘤]