基于JMP软件分析的D-阿洛酮糖结晶工艺研究  

Optimization of crystallization process of D-psicose based on JMP software analysis

作　　者：邢敏钰 龚俊波 杜世超 张强 郭盛争 冉淦侨 XING Minyu;GONG Junbo;DU Shichao;ZHANG Qiang;GUO Shengzheng;RAN Ganqiao(Bio-Agriculture Institute of Shaanxi,Xi’an 710043;National Engineering Research Center of Industry Crystallization Technology,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072;School of Pharmaceutical Sciences(Shandong Analysis and Testing Center),Qilu University of Technology,Jinan 250014)

机构地区：[1]陕西省生物农业研究所,西安710043 [2]天津大学化工学院国家工业结晶工程技术研究中心,天津300072 [3]齐鲁工业大学药学院(山东省分析测试中心),济南250014

出　　处：《中国食品添加剂》2023年第8期1-9,共9页China Food Additives

基　　金：陕西省重点研发计划(2021GXLH-Z-016);陕西省科学院科技计划项目(2017K-13,2019K-09)。

摘　　要：目的:基于JMP软件分析D-阿洛酮糖结晶工艺,建立一种可高效从糖浆中回收D-阿洛酮糖的结晶方法。方法:首先,利用动态法测定了D-阿洛酮糖在溶剂中的溶解度,确定结晶溶剂种类。其次,通过单因素实验确定结晶初始条件;通过JMP软件设计部分析因实验,并考察降温速率、搅拌速率与晶种添加量对结晶收率的影响。最后,采用JMP软件分析工艺过程,建立结晶收率预测模型,确定最优的结晶工艺条件。结果:基于JMP软件分析D-阿洛酮糖结晶工艺,建立了收率预测模型,并预测得到最佳的结晶条件为:起始温度60℃,终止温度20℃,浆醇比2∶1,搅拌转速300 r/min,降温速率1.5℃/h,晶种添加量10%。该条件下结晶收率达91.36%,与预测值92.85%无显著性差异,且晶体质量良好。The aim of this study was to analyze the crystallization process of D-psicose based on JMP software analysis and to establish an efficient crystallization method for recovering D-psicose from syrup.The solubility of D-psicose in different solvents was determined by dynamic method,and appropriate crystallization solvent was selected.The initial conditions of crystallization were determined by single factor experiments,and the effects of cooling rate,stirring speed and seed addition on the crystallization yield were investigated by partial factorial experiments designed by JMP software.Based on the analysis of crystallization process,a predicting model of crystallization yield was established to determine the optimal crystallization process conditions.Based on experimental data analysis of JMP software,the optimal crystallization conditions were as follows:starting temperature 60℃,ending temperature 20℃,pulp to alcohol ratio 2∶1(w/w),stirring speed 300 r/min,cooling rate 1.5℃/h and crystal seed amount 10%.Under the above optimal conditions,the yield of crystallization was achieved 91.36%,which was very close to the predicted value of 92.85%.The quality of the crystal was also very good.

关 键 词：D-阿洛酮糖 结晶 工艺参数 JMP 

分 类 号：TS202.3[轻工技术与工程—食品科学]