苯磺酸瑞马唑仑用于无痛胃肠镜检查对患者精神运动功能恢复的影响  

Effect of remimazoalam besylate on the recovery of psychomotor function in patients after painless gastrointestinal endoscopy

作　　者：李梦迪 王博文 韩礼业 张世杰 刘晓翔 王汝亭 赵晓虹 高成杰 Li Mengdi;Wang Bowen;Han Liye;Zhang Shijie;Liu Xiaoxiang;Wang Ruting;Zhao Xiaohong;Gao Chengjie(Postgraduate Training Base,the 960th Hospital of the PLA Joint Logistics Support Force,Jinan 250031,China;Department of Anesthe-siology,Weifang Medical College,Weifang 261000,China;Department of Anesthesiology,the 960th Hospital of the PLA Joint Logistics Support Force,Jinan 250031,China)

机构地区：[1]中国人民解放军联勤保障部队第九六〇医院研究生培养基地,济南250031 [2]潍坊医学院麻醉学系,潍坊261000 [3]中国人民解放军联勤保障部队第九六〇医院麻醉科,济南250031

出　　处：《国际麻醉学与复苏杂志》2023年第7期715-719,共5页International Journal of Anesthesiology and Resuscitation

摘　　要：目的探讨苯磺酸瑞马唑仑用于无痛胃肠镜检查对患者精神运动功能恢复的影响。方法选择拟接受择期无痛胃肠镜检查的患者120例,ASA分级Ⅰ、Ⅱ级,年龄18~70岁,按随机数字表法分为丙泊酚组(P组)、苯磺酸瑞马唑仑组(R组)、苯磺酸瑞马唑仑联合丙泊酚组(S组),每组40例。患者诱导均采用静脉注射瑞芬太尼0.2μg/kg,P组静脉注射丙泊酚1.0~2.0 mg/kg、R组静脉注射苯磺酸瑞马唑仑0.2 mg/kg、S组静脉注射苯磺酸瑞马唑仑7 mg复合丙泊酚0.5 mg/kg进行麻醉。各组患者恢定向力后进行精神运动功能测试:①采用Romberg试验,评估并记录恢复定向力5 min后能独立坐起且10 min后能稳定站立的患者例数;②患者恢复定向力15 min后依次进行手指轻叩试验、选择反应时(choice reaction time,CRT)测试、数字符号转换试验(digit‑symbol substitution test,DSST)、数字连接试验(numberal connection test‑A,NCT‑A),且各项测试每5 min进行1次,直至测试结果恢复至基线水平,记录各项测试指标恢复时间。记录患者检查时间、苏醒时间、离院时间、不良反应(呼吸抑制、低血压)及追加药物次数>3次的患者例数。结果R组、S组患者手指轻叩试验、CRT测试、DSST、NCT‑A的恢复时间短于P组(P<0.05);S组患者CRT测试、DSST、NCT‑A的恢复时间短于R组(P<0.05),手指轻叩试验恢复时间长于R组(P<0.05)。S组恢复定向力5 min后能独立坐起且10 min后能稳定站立的患者例数多于P组和R组(P<0.05)。与P组比较,R组患者苏醒时间延长、离院时间缩短(P<0.05),S组患者苏醒时间、离院时间缩短(P<0.05);与R组比较,S组患者苏醒时间缩短(P<0.05),离院时间差异无统计学意义(P>0.05)。与P组比较,R组、S组患者呼吸抑制、低血压的发生率降低(P<0.05);与R组比较,S组、P组追加药物次数>3次的患者例数减少(P<0.05)。结论苯磺酸瑞马唑仑用于无痛胃肠镜检查,患者精神运动功能恢复�Objective To investigate the effect of remimazolam besylate on the recovery of psychomotor function in patients undergoing painless gastrointestinal endoscopy.Methods A total of 120 patients,ASAⅠorⅡ,aged 18−70 years,who were sched‑uled for painless gastrointestinal endoscopy,were selected.According to the random number table method,they were divided into three groups(n=40):a propofol group(group P),a remimazolam besylate group(group R)and a remimazolam besylate combined with propofol group(group S).Then,the patients were intravenously injected with remifentanil at 0.2μg/kg for anesthesia induction.Pa‑tients in group P were intravenously injected with propofol at 1.0−2.0 mg/kg,group R was intravenously injected with remimazolam be‑sylate at 0.2 mg/kg and those in group S was intravenously injected with 7 mg remimazolam besylate combined with 0.5 mg/kg propofol.The psychomotor function test was performed after the recovery of orientation.①The Romberg test was used to evaluate and record the number of patients who could sit up independently 5 min after regaining orientation and stand stably 10 min after regaining orientation.②Then,15 min after the patients regained orientation,the finger tapping test,choice reaction time(CRT)test,digit‑symbol substitution test(DSST)and number connection test‑A(NCT‑A)were conducted successively,and each test was carried out once every 5 min until the results returned to the baseline.The recovery time of each indicator was recorded.The time of examination,recovery and dis‑charge,as well as adverse reactions(respiratory depression,hypotension)and the number of patients who added drugs for more than 3 times were recorded.Results Group R and group S showed shorter recovery time of the finger tapping test,CRT,DSST and NCT‑A than group P(P<0.05).Compared with group R,group S presented decreases in the recovery time of CRT,DSST and NCT‑A(P<0.05)and increases in the recovery time of the finger tapping test(P<0.05).The number of patients who could sit up indepen

关 键 词：瑞马唑仑 丙泊酚 瑞芬太尼 胃肠镜检查 精神运动功能 

分 类 号：R57[医药卫生—消化系统]