艾普拉唑钠治疗消化性溃疡的疗效及对患者前列腺素E_(2)水平、溃疡愈合质量的影响  

Efficacy of ilaprazole sodium in treating peptic ulcer and its effect on prostaglandin E_(2) and ulcer healing quality

作　　者：张亚楠 聂园园 Zhang Yanan;Nie Yuanyuan(Department of Internal Medicine,Pudong Hospital,Zhongyuan Oilfield Medical and Health Service Center,Puyang Henan 457001,China;Department of Cardiology,Puyang Oilfield General Hospital,Puyang Henan 457001,China)

机构地区：[1]中原油田医疗卫生服务中心濮东医院内科,河南濮阳457001 [2]濮阳市油田总医院心内科,河南濮阳457001

出　　处：《保健医学研究与实践》2023年第5期28-31,共4页Health Medicine Research and Practice

基　　金：河南省中医药科学研究专项课题(2019JDZX2094)。

摘　　要：目的探讨艾普拉唑钠治疗消化性溃疡的疗效及对患者血清前列腺素E_(2)(PGE_(2))水平、溃疡愈合质量的影响。方法选取2019年2月—2022年1月中原油田医疗卫生服务中心濮东医院诊治的70例消化性溃疡患者作为研究对象,采用随机数字表法分为观察组与对照组,每组35例。对照组患者采用基于奥美拉唑的三联疗法治疗,观察组患者采用基于艾普拉唑钠的三联疗法治疗,2组患者均治疗3个月。比较2组患者的临床疗效及治疗前后血清PGE_(2)水平、溃疡愈合质量等。结果观察组患者的治疗总有效率为97.14%(34/35),高于对照组的77.14%(27/35),差异有统计学意义(χ^(2)=4.590,P=0.032)。观察组患者治疗期间不良反应发生率为5.71%(2/35),低于对照组的31.43%(11/35),差异有统计学意义(χ^(2)=7.652,P=0.006)。观察组患者治疗后幽门螺杆菌根除率为97.14%(34/35),高于对照组的77.14%(27/35),差异有统计学意义(χ^(2)=4.590,P=0.032)。2组患者治疗前溃疡面直径比较,差异无统计学意义(P>0.05);2组患者治疗后溃疡面直径均小于治疗前,且观察组小于对照组,差异均有统计学意义(P<0.05)。2组患者治疗前血清PGE_(2)水平比较,差异无统计学意义(P>0.05);2组患者治疗后血清PGE_(2)水平均高于治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。结论艾普拉唑钠治疗消化性溃疡的疗效较好,有助于提高溃疡愈合质量及幽门螺杆菌根除率,且安全性较好,值得临床推广应用。Objective This study aimed to investigate the effect of ilaprazole sodium on peptic ulcers and its effect on prostaglandin E_(2)(PGE_(2))level and ulcer healing quality.Methods A total of 70 patients with peptic ulcers who were diagnosed and treated in Pudong Hospital,Zhongyuan Oilfield Medical and Health Service Center from February 2019 to January 2022 were selected as the study participants.They were randomly assigned to the observation group and the control group,with 35 cases in each group.Patients in the control group received omeprazole-based triple therapy;patients in the observation group received ilaprazole sodium-based triple therapy,with patients in both groups receiving treatment for 3 months.The clinical efficacy,serum PGE_(2) level before and after treatment,and ulcer healing quality were compared between the two groups.Results The overall response rate in the observation group was 97.14%(34/35),which was significantly higher than that in the control group(77.14%,27/35;χ^(2)=4.590,P=0.032).The incidence rate of adverse reactions during treatment in the observation group was 5.71%(2/35),which was significantly lower than that in the control group(31.43%,11/35;χ^(2)=7.652,P=0.006).The eradication rate of Helicobacter pylori after treatment in the observation group was 97.14%(34/35),which was significantly higher than that in the control group(77.14%,27/35;χ^(2)=4.590,P=0.032).The difference in the diameter of the ulcer surface before treatment between the two groups demonstrated no statistical significance(P>0.05).The diameter of the ulcer surface after treatment in the two groups was decreased,and the observation group was smaller than the control group,with statistical significance(P<0.05).The difference in the serum PGE_(2) level before treatment between the two groups showed no statistical significance(P>0.05).The serum PGE_(2) level after treatment in the two groups was increased,and the observation group was higher than the control group,with statistical significance(P<0.05).Conclusion Ilapr

关 键 词：艾普拉唑钠 消化性溃疡 前列腺素E_(2) 溃疡愈合质量 

分 类 号：R573.1[医药卫生—消化系统]