RNAm^(5)C甲基化修饰在消化系统癌症中的作用机制  

Mechanisms of RNA m^(5)C methylation in digestive system cancers

作　　者：张心煜 程文栎 张文娟[1] ZHANG Xinyu;CHENG Wenli;ZHANG Wenjuan(Department of Public Health and Preventive Medicine,Jinan University,Guangzhou 510632,Guangdong,China)

机构地区：[1]暨南大学基础医学与公共卫生学院,广东广州510632

出　　处：《暨南大学学报（自然科学与医学版）》2023年第3期259-266,共8页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：广东省基础与应用基础研究基金项目(2021A1515011220,2023A1515010353);广东省特支计划“百千万工程”青年拔尖人才项目(87316004);暨南大学医学教学与教育管理改革研究项目(2021YXJG003)。

摘　　要：RNA的5-甲基胞嘧啶(m^(5)C)甲基化是一种常见的转录后修饰类型,该RNA甲基化修饰过程受到RNA m^(5)C甲基转移酶及其结合蛋白等调控体系的联合作用。RNA m^(5)C甲基化调控与消化系统癌症密切相关,其水平异常影响癌症的发生发展进程,m^(5)C水平升高可促进特定的癌细胞增殖、侵袭和迁移。RNA m^(5)C甲基化及调节体系有望成为消化系统癌症的新型生物标志物,为其预防、干预和治疗提供潜在的作用靶点。One of the common RNA post-transcriptional changes,5-methylcytosine(m^(5))methylation,is controlled by the cooperative action of m^(5) methyltransferases and binding proteins.Tumor growth is influenced by the abnormal expression of RNA m^(5),which is directly linked to cancers of the digestive system.Specific cancer cells are encouraged to proliferate,migrate and invade as a result of the elevated level of m^(5).In digestive system cancers,it is envisaged that RNA m^(5) methylation and its regulatory mechanism may become novel biomarkers,providing potential targets for intervention,prevention and treatment.

关 键 词：RNA甲基化 5-甲基胞嘧啶(m^(5)C) 消化系统癌症 m^(5)C调节因子 

分 类 号：R735[医药卫生—肿瘤]