祛黄褐斑中药保健食品组方规律及用药特点分析  

Analysis on Formulation Regularity and Characteristics of Melasma-Relieving Chinese Medicinal Health Products

作　　者：张娟娟 刘海珍 覃秋艳 郑慧娥 朱明芳[2] Zhang Juanjuan;Liu Haizhen;Qin Qiuyan;Zheng Hui'e;Zhu Mingfang(The Second Hospital Integrated Traditional Chinese and Western Medicine Affiliated to Hunan University of Chinese Medicine/Liuyang Hospital of Chinese Medicine,Liuyang 410300,China;The Second Hospital Affiliated to Hunan University of Chinese Medicine,Changsha 410005,China)

机构地区：[1]湖南中医药大学附属第二中西医结合医院/浏阳市中医医院,湖南浏阳410300 [2]湖南中医药大学第二附属医院,湖南长沙410005

出　　处：《亚太传统医药》2023年第8期163-167,共5页Asia-Pacific Traditional Medicine

基　　金：长沙市自然科学基金(kq2208497);湖南省高层次卫生人才“225”工程培养项目(湘卫函[2018]445号);湖南省中医药领军人才培养项目(湘中医药[2021]10号)。

摘　　要：目的:总结分析当前祛黄褐斑保健食品现状,为其组方和产品开发提供参考依据。方法:从国家市场监督管理总局(SAMR)特殊食品安全监督管理司公布的具有祛黄褐斑功能的保健食品中筛选含中药原料的配方,应用Microsoft Excel和中医传承辅助平台(V2.5)统计分析配方特点。结果:共搜集到345种具有祛黄褐斑功能的保健食品,其中256种配方含有中药原料,筛选出符合纳入标准的方剂247条,涉及中药原料142味。使用频次≥20的中药原料12味,累计使用575次,高频药为当归、珍珠、红花、芦荟、枸杞子、丹参、茯苓、白芷、玫瑰花、黄芪、桃仁、白芍。基于无监督的熵层次聚类分析,得到新方核心组合16个,祛黄褐斑功能的保健食品新处方8个。结论:祛黄褐斑保健食品常使用当归、红花、丹参等活血化瘀中药,疗效确切。新组方组合与中医治疗黄褐斑治则基本契合,即活血化瘀、补益肝肾、疏肝健脾,同时重视解毒法,为研发祛黄褐斑中药保健食品提供了新方法和新思路。Objective:This study summarizes and analyzes the current status of melasma-relieving health products,aiming at providing references for the formulation and development of melasma-relieving health products.Methods:The information of melasma-relieving health products were searched from the Department of Special Food Safety Supervision and Administration of the State Administration for Market Regulation(SAMR),the formula of health food containing traditional Chinese medicine raw materials was screened out.Microsoft Excel and the Traditional Chinese Medicine Inheritance Support System V2.5(Version 2.5)were employed to count and analyze the characteristics of formulations.Results:A total of 345kinds of melasma-relieving health products were obtained in SAMR,of which 256kinds contained traditional Chinese medicine raw materials,and a total of 247prescriptions that met the inclusion criteria were screened out,involving 142kinds of TCM(Traditional Chinese Medicine).Twelve Chinese herbal medicines showed a usage frequency≥20,with 575times in use totally,The high frequency drugs were Danggui,Zhenzhu,Honghua,Luhui,Gouqizi,Danshen,Fuling,Baizhi,Meiguihua,Huangqi,Taoren,Baishao.Based on the unsupervised hierarchical entropy clustering analysis,16new core combinations were obtained,and 8new prescriptions for the melasma-relieving were obtained.Conclusion:The Blood-activating and Stasis-eliminating Drugs such as Danggui,Honghua,Danshen are commonly used in the melasma-relieving health food,They have definite curative effect.The new combination of formulas is basically in line with the principles of TCM theories in relieving melasma.That is,blood-activating and stasis-eliminating,tonifying the liver and kidney,soothing Liver and activating Spleen method,and attaching importance to detoxification methods to provide new methods and new ideas for the research and development of melasma-relieving Chinese medicinal health products.

关 键 词：祛黄褐斑 保健食品 组方 用药规律 中医传承辅助平台 

分 类 号：R275[医药卫生—中医皮科]