角膜缘干细胞缺乏影像学诊断的研究进展  

Research progress on imagine diagnosis of limbal stem cell deficiency

作　　者：王乐滢 梁庆丰 Wang Leying;Liang Qingfeng(Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Institute of Ophthalmology,Beijing Key Laboratory of Ophthalmology&Visual Sciences,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院北京同仁眼科中心、北京市眼科研究所、北京市眼科学与视觉科学重点实验室,北京100730

出　　处：《中华眼科杂志》2023年第8期673-676,共4页Chinese Journal of Ophthalmology

摘　　要：角膜缘干细胞缺乏(LSCD)是由于角膜缘干细胞数量或功能异常导致的角膜上皮稳态失衡,其症状缺乏特异性,且裂隙灯检查难以与其他眼表疾病鉴别。印迹细胞学实验室检查只能在一定范围内进行定性诊断。近年来,出现了新型影像学检查,为LSCD的诊断和分期带来了新的曙光。本文归纳总结了多种检查方法,包括眼前节光学相干层析成像术观察角膜上皮厚度和角膜缘Vogt栅栏状结构、眼前节相干光层析血管成像术检测角膜新生血管、角膜活体共聚焦显微镜测量角膜上皮厚度、基底细胞密度和基底膜下神经,以及全场/频域光学相干层析成像术在LSCD诊断方面的应用。旨在为LSCD的临床诊疗及相关研究奠定基础。Limbal stem cell deficiency(LSCD)is an ocular surface disease resulting from a reduction and/or dysfunction of limbal stem cells.The symptoms of LSCD are non-specific and can be difficult to distinguish from other ocular surface diseases through slit-lamp examination.Impression cytology is currently considered the gold standard for LSCD diagnosis;however,it is a qualitative method with low sensitivity.Nonetheless,emerging imaging techniques offer quantitative diagnosis and staging of LSCD.This review article examines four imaging methods and their associated parameters for diagnosing LSCD:optical coherence tomography,which measures corneal epithelial thickness;optical coherence tomography angiography,which detects corneal neovascularization;in vivo confocal microscopy,which measures corneal epithelial thickness,subbasal nerve density,and corneal basal cell density;and future applications of full-field/spectral-domain optical coherence tomography.

关 键 词：角膜缘干细胞缺乏 体层摄影术 光学相干 活体显微镜检查 显微镜检查 共焦 眼前半段 上皮 角膜 

分 类 号：R772.2[医药卫生—眼科]