女性帕金森病患者剂末现象的临床特征和危险因素分析  

Analysis of the Clinical Characteristics and Risk Factors of Wearing-off Phenomenon in Fe⁃male Patients with Parkinson’s Disease

作　　者：万志荣[1] 赵静[1] 解金金 李继来[1] 王培福[1] 冯涛[3] 杜继臣[1] WAN Zhirong;ZHAO Jing;XIE Jinjin;LI Jilai;WANG Peifu;FENG Tao;DU Jichen(Department of Neurology,Aerospace Central Hospital,Beijing 100049,China;The First People’s Hospital of Changzhou Jintan,Jiangsu Changzhou 213200,China;Department of movement disorders,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]航天中心医院神经内科,北京100049 [2]常州市金坛第一人民医院,江苏常州213200 [3]首都医科大学附属北京天坛医院运动障碍性科,北京100050

出　　处：《神经损伤与功能重建》2023年第8期461-464,473,共5页Neural Injury and Functional Reconstruction

基　　金：2021年航天中心医院科研基金项目(No.YN202102)。

摘　　要：目的:调查女性帕金森病(PD)患者剂末现象(WO)的临床特征和危险因素。方法:采用横断面研究,连续收集符合PD诊断标准的女性患者病例资料,收集一般人口学资料和临床数据(运动症状、非运动症状、是否合并WO、服药情况等),并进行分析。结果:共收集女性PD患者146例,根据患者是否发生WO将患者分为WO组63例(43.2%)和no-WO组83例。与No-WO组相比,WO组发病年龄更早、体质量和BMI更低、病程更长、病情更重、每日左旋多巴等效剂量(LEDD)更大,更容易合并抑郁症(均P<0.05);多因素Logistic回归分析提示,发病年龄大(OR=0.923,P=0.003)是女性WO的保护因素,而病程长(OR=1.256,P=0.003)、H-Y分期高(OR=2.074,P=0.011)是WO的危险因素。结论:女性PD患者发生WO现象的危险因素包括发病年龄小、病程长、H-Y分期高。Objective:This study aimed to investigate the clinical characteristics and risk factors for the wearing-off(WO)phenomenon of Parkinson’s disease(PD)in female patients.Methods:In this cross-sectional study,we continuously collected the clinical data of female patients who met the PD diagnostic criteria.General demographic and clinical data,including motor symptoms,non-motor symptoms,possible combination with WO,and drug-related factors,were collected.Results:A total of 146 female patients with PD were enrolled and divided into the WO group(n=63 cases,43.2%),and the no-WO group(n=83 cases).Compared with the no-WO group,the WO group had an earlier age of onset,lower body weight and BMI,longer disease duration,more severe disease,higher Levodopa Equivalent Daily Dose(LEDD),and a greater risk of complication with depression(all,P<0.05).Multivariate logistic regression analysis revealed that older age at onset(OR=0.923,P=0.003)was a protective factor for WO in female patients,while longer disease duration(OR=1.256,P=0.003)and higher Hoehn and Yahr(H-Y)stage(OR=2.074,P=0.011)were risk factors for WO.Conclusion:The risk factors of the WO phenomenon in female patients with PD include young age at onset,longer disease duration,and high H-Y stage.

关 键 词：帕金森病 女性 剂末现象 危险因素 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.05[医药卫生—临床医学] R742