形觉剥夺性近视的视网膜调控机制研究进展  

Advances in the retinal regulation mechanism of form-deprivation myopia

作　　者：冯娇娇 宋继科[1,2] 毕宏生[2] FENG Jiaojiao;SONG Jike;BI Hongsheng(Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong Province,China;Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine,Shandong Academy of Eye Disease Prevention and The\|rapy,Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases,Shandong Provincial Clinical Medical Research Center of Optometry and Adolescent Low Vision Prevention and Control,Jinan 250002,Shandong Province,China)

机构地区：[1]山东中医药大学,山东省济南市250014 [2]山东中医药大学附属眼科医院,山东省眼病防治研究院,山东省中西医结合眼病防治重点实验室,山东省眼视光与青少年视力低下防控临床医学研究中心,山东省济南市250002

出　　处：《眼科新进展》2023年第9期736-741,共6页Recent Advances in Ophthalmology

基　　金：国家重点研发计划(编号:2019YFC1710203)。

摘　　要：形觉剥夺性近视(FDM)是由于视网膜接收不到清晰的物像,从而导致眼轴异常伸长,进而诱导近视发生。由于上睑下垂、先天性白内障、角膜混浊和玻璃体积血等原因导致的形觉剥夺引发的近视,其机制可能与在动物模型上观察到的FDM的机制类似。动物模型的研究已经证明了眼部生长和屈光发育的视觉引导以及视网膜调控的存在。视网膜是首先感知异常视觉信号的组织,探讨FDM发生发展机制的关键在于阐明异常的视觉信号输入如何被视网膜所感知并产生相应的生理病理改变。目前的研究已经确定了如多巴胺、视黄酸、血管活性肠肽、黑视蛋白等视网膜神经递质以及视网膜离子外排机制的重要作用。基因组学、蛋白质组学、代谢组学等技术发展使得从宏观层面了解形觉剥夺时视网膜发生的整体改变成为可能,为进一步探究FDM的视网膜调控机制提供了重要的数据支持。Form-deprivation myopia(FDM)is induced by the abnormal elongation of the eye axis due to the failure of the retina to receive clear object images.The mechanism of FDM triggered by ptosis,congenital cataract,corneal opacity,and vitreous hemorrhage may be similar to that observed in animal models with FDM.Studies on FDM animal models have demonstrated the existence of visual guidance on eye growth and refractive development as well as retinal regulation.The retina is the first to perceive abnormal visual signals;thus,to investigate the mechanism of FDM occurrence and development,it is crucial to clarify how the retina perceives abnormal visual signal input and produces the corresponding physiopathological changes.Current studies have identified the significance of retinal neurotransmitters such as dopamine,retinoic acid,vasoactive intestinal peptide,and melanopsin,as well as retinal ion efflux mechanisms.Technological development such as genomics,proteomics,and metabolomics has made it possible to understand the overall changes that occur in the retina during form deprivation at a macroscopic level,providing valuable data for further studies on the retinal regulation mechanisms of FDM.

关 键 词：形觉剥夺性近视 多巴胺 视黄酸 血管活性肠肽 黑视蛋白 组学技术 

分 类 号：R778.11[医药卫生—眼科]