副肿瘤性天疱疮伴发纵隔巨大胸腺瘤^(18)F-FDG PET/CT显像1例  

Paraneoplastic pemphigus with mediastinal giant thymoma ^(18)F-FDG PET/CT imaging:a case report

作　　者：黄文鹏 邱永康 陈钊 廖栩鹤[1] 张旭初[1] 康磊[1] 范岩[1] Wenpeng Huang;Yongkang Qiu;Zhao Chen;Xuhe Liao;Xuchu Zhang;Lei Kang;Yan Fan(Department of Nuclear Medicine,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院核医学科,北京100034

出　　处：《国际放射医学核医学杂志》2023年第7期450-453,共4页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：北京市杰出青年科学基金(JQ21025);北大医学青年科技创新发展平台青年培育基金(BMU2022PY006);中央高水平医院临床科研北京大学第一医院跨学科交叉研究专项(2023IR17)。

摘　　要：副肿瘤性天疱疮(PNP)是一种与肿瘤相关的皮肤黏膜自身免疫性疾病,其伴发纵隔巨大胸腺瘤在临床较罕见.笔者报道了 1例PNP患者,从临床、组织病理学、治疗、^(18)F-氟脱氧葡萄糖(FDG)PET/CT显像等方面分析了 PNP的特点,通过文献复习加深了对该病的认识.多形性皮肤损害患者应考虑PNP的可能,其诊断基于临床表现、组织病理学检查以及免疫荧光检查.笔者通过PET/CT显像发现隐匿性的恶性肿瘤,辅助临床医师了解胸腺瘤与PNP的内在联系,提高术前的诊断准确率,并为治疗方案的选择提供重要依据.Paraneoplastic pemphigus(PNP)is a tumor-related autoimmune disease affecting the skin and mucosa,while the occurrence of mediastinal giant thymoma with PNP is infrequent in clinical practice.In this study,the authors presents a case of PNP and conducts a comprehensive analysis of its clinical,histopathological,therapeutic,and ^(18)F-fluorodeoxyglucose(FDG)PET/CT imaging characteristics,thereby deepening the understanding of this disease through literature review.The possibility of PNP should be considered in patients with polymorphic skin lesions,the diagnosis of which is based on clinical presentation,histopathologic examination,and immunofluorescence.The autors found occult malignant tumors by PET/CT imaging,which assisted clinicians to understand the intrinsic connection between thymoma and PNP,improved the diagnostic accuracy of preoperative diagnosis,and provided an important basis for the choice of treatment plan.

关 键 词：免疫荧光检查 PET/CT显像 副肿瘤性天疱疮 氟脱氧葡萄糖 自身免疫性疾病 胸腺瘤 临床医师 组织病理学 

分 类 号：R573.3[医药卫生—消化系统]