Porous insights:IpaH7.8 reveals crystal-clear differences of gasdermins in mice and men  

作　　者：Friedrich Alexander von Samson-Himmelstjerna Benedikt Kolbrink Stefan Krautwald 

机构地区：[1]Department of Nephrology and Hypertension,University Hospital Schleswig-Holstein,24105 Kiel,Germany

出　　处：《Signal Transduction and Targeted Therapy》2023年第7期3209-3210,共2页信号转导与靶向治疗（英文）

基　　金：The authors’work is funded by the Medical Faculty of CAU Kiel(to F.A.v.S-H.and B.K.),and a grant from Dr.Werner Jackstädt-Stiftung(to S.K.).S.K.is also supported by the infrastructure of the DFG Cluster of Excellence 2167 Precision Medicine in Chronic Inflammation.The authors would like to thank Maja Lucia Messtorff for creating the figure.

摘　　要：Two recent back-to-back papers published in Nature provide new insights into the structural basis of gasdermin B(GSDMB)targeting by the secreted Shigella virulence effector IpaH7.8,the regulation of GSDMB’s pore-forming pyroptotic activity by alternative splicing,and into the inter-species differences regarding IpaH7.8-mediated inhibition of gasdermin D(GSDMD)activity.

关 键 词：INSIGHT SHIGELLA activity 

分 类 号：R730.2[医药卫生—肿瘤]