Dicoumarol is an effective post-exposure prophylactic for SARS-CoV-2 Omicron infection in human airway epithelium  

作　　者：Yang Peng Shi-ying Chen Zhao-ni Wang Zi-qing Zhou Jing Sun Gui-an Zhang Jia Li Lei Wang Jin-cun Zhao Xiao Xiao Tang De-Yun Wang Nan-shan Zhong 

机构地区：[1]State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Medical University,Guangzhou,Guangdong,China [2]Department of Otolaryngology,Infectious Diseases Translational Research Program,Yong Loo Lin School of Medicine,National University of Singapore,Singapore,Singapore [3]Guangzhou Laboratory,Guangzhou,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第7期3455-3465,共11页信号转导与靶向治疗（英文）

基　　金：The authors would like to thank the study participants who donated their samples for the advancement of scientific knowledge.The authors would also like to thank Dr.Jennie Wong(from the Medical and Scientific Communication,Research Support Unit,Yong Loo Lin School of Medicine,National University of Singapore,Singapore)for assistance in the language editing of this manuscript.This work was supported by The National High-Level Talents Program(X.X.T.),Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01S155);Guangzhou Institute of Respiratory Health Open Project(X.X.T.);the Postdoctoral Science Foundation of China(2022M710897,Y.P.);the Postdoctoral Startup Foundation of Guangzhou City(Y.P.);Zhongnanshan Medical Foundation of Guangdong Province(ZNSA-2020013,Z.Q.Z.).

摘　　要：Repurposing existing drugs to inhibit SARS-CoV-2 infection in airway epithelial cells(AECs)is a quick way to find novel treatments for COVID-19.Computational screening has found dicoumarol(DCM),a natural anticoagulant,to be a potential SARS-CoV-2 inhibitor,but its inhibitory effects and possible working mechanisms remain unknown.Using air-liquid interface culture of primary human AECs.

关 键 词：OMI INFECTION EPITHELIUM 

分 类 号：R563.1[医药卫生—呼吸系统]