内皮细胞分泌与基质微环境  

Endothelial cell secretion and matrix microenvironment

作　　者：乔梓琪 赵霄美 罗金才 QIAO Ziqi;ZHAO Xiaomei;LUO Jincai(Institute of Molecular Medicine,College of Future Technology,Peking University,Beijing 100871,China)

机构地区：[1]北京大学未来技术学院分子医学研究所,北京100871

出　　处：《生命的化学》2023年第7期1049-1058,共10页Chemistry of Life

基　　金：国家自然科学基金项目(81930011)。

摘　　要：作为人体管脉系统的重要的组成部分,内皮细胞覆盖心脏、血管和淋巴管的最内层,在包括物质运输、细胞增殖、生理性止血、血管新生、肿瘤和炎症等多种生理及病理过程中发挥重要的调控作用。除此之外,内皮细胞还可以通过分泌作用,介导管腔内外和基质微环境之间的相互作用。内皮细胞能够分泌多种生物活性物质,分为持续性的组成型分泌和在多种刺激因素调控下的囊泡分泌。在生理条件下,内皮细胞分泌对维持细胞外环境的稳态起到至关重要的作用,如生理性止血、血管新生等;而在病理条件下,内皮细胞也能够通过分泌作用来应对周围环境的失调,如损伤修复及调控肿瘤微环境等。全面了解淋巴管和血管内皮细胞的分泌功能及其调控基质微环境的机制为其调控生理功能的研究提供了方向,并为寻找治疗肿瘤、炎症等多种疾病的新靶点奠定了基础。As an important part of the vasculature,endothelial cells cover the innermost layer of the heart,blood vessels and lymph vessels,which plays an important regulatory role in a variety of physiological and pathological processes,including material transport,cell proliferation,hemostasis,angiogenesis,tumorigenesis and inflammation.In addition,it can also mediate the interaction between endovascular cells and extracellular matrix microenvironment through the secretion of endothelial cells.Endothelial cells can secrete a variety of bioactive substances,which can be classified into continuous constitutive secretion and exocytosis of membranous vesicles under the regulation of multiple stimuli.Under physiological conditions,endothelial cell secretion plays a crucial role in maintaining the homeostasis of the extracellular environment,such as physiological hemostasis and angiogenesis.Under pathological conditions,endothelial cells can also respond to environmental disorders through secretion,such as damage repair and the regulation of tumor microenvironment.A comprehensive understanding of the secretory function of lymphatic vessels and blood endothelial cells and the mechanism of their regulation functions of matrix microenvironment will provide a direction for the study of their regulation of physiological functions,and lay a foundation for searching for new targets of the treatment of various diseases.

关 键 词：内皮 内皮细胞分泌 细胞外基质 血管新生 肿瘤微环境 

分 类 号：R363[医药卫生—病理学]