细胞外基质与肿瘤休眠  

Extracellular matrix and tumor dormancy

作　　者：戴大有 木司塔巴·木台力甫 张一宁[2] 李冬雪 张志刚[1] DAI Dayou;MUSITABA Mutailifu;ZHANG Yining;LI Dongxue;ZHANG Zhigang(State Key Laboratory of Systems Medicine for Cancer,Shanghai Cancer Institute,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200032,China;Department of Pediatric Endocrinology,and Genetic/Metabolic Disorders,Bathune First Hospital of Jilin University,Changchun 130012,China)

机构地区：[1]上海交通大学医学院附属仁济医院上海市肿瘤研究所,肿瘤系统医学全国重点实验室,上海200032 [2]吉林大学附属白求恩第一医院小儿内分泌遗传代谢科,长春130012

出　　处：《生命的化学》2023年第7期1108-1117,共10页Chemistry of Life

基　　金：国家自然科学基金重点项目(82230087)。

摘　　要：肿瘤休眠是目前肿瘤研究和治疗的难点之一,治疗后的肿瘤常因肿瘤休眠而发生晚期复发。虽然目前针对肿瘤休眠已有大量的研究,但是肿瘤发生休眠的原因、肿瘤休眠的位置,以及让肿瘤进入休眠的方法等仍是未解之谜。本文介绍了肿瘤休眠研究的历史,以及目前研究者针对肿瘤休眠提出的两种学说,即肿瘤细胞和肿瘤块休眠学说,简述了目前一些肿瘤休眠的研究方法和模型;还总结了目前治疗肿瘤休眠的方案,并分析了肿瘤休眠与细胞外基质的关系,指出通过靶向细胞外基质内容治疗肿瘤休眠的可行性,以期为肿瘤休眠的研究和治疗提供新的思路。Tumor dormancy presents a significant challenge in both tumor research and treatment,as late recurrence frequently occurs following treatment.Despite extensive research on the topic,the underlying causes,specific locations,and effective methods for inducing tumor dormancy remain unresolved.In this review,we present an overview of the research history of tumor dormancy,including the two theories proposed by researchers,namely the tumor cell and tumor mass dormancy theories.Additionally,current research methods and models of tumor dormancy are briefly discussed.Subsequently,we introduced the current treatment plans for tumor dormancy here,analyzed the relationship between tumor dormancy and extracellular matrix,and pointed out the feasibility of targeting extracellular matrix content to treat tumor dormancy,in order to provide new ideas for the research and treatment of tumor dormancy.

关 键 词：肿瘤休眠 细胞外基质 胶原蛋白 靶向治疗 

分 类 号：R730.2[医药卫生—肿瘤]