细胞外基质与T细胞介导的抗肿瘤免疫应答  

Extracellular matrix and T cell-mediated anti-tumor immune response

作　　者：刘祥明 葛高翔 LIU Xiangming;GE Gaoxiang(State Key Laboratory of Cell Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai 200031,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院分子细胞科学卓越创新中心,中国科学院生物化学与细胞生物学研究所,细胞生物学国家重点实验室,上海200031 [2]中国科学院大学,北京100049

出　　处：《生命的化学》2023年第7期1118-1125,共8页Chemistry of Life

基　　金：国家重点研发计划项目(2020YFA0803203);国家自然科学基金项目(32070789);上海市市级科技重大专项。

摘　　要：肿瘤组织与正常组织中细胞外基质蛋白的表达谱显著不同。细胞外基质的异常沉积、重塑和刚性等理化性质的改变是多种实体肿瘤的普遍特征,并往往与临床治疗的抵抗密切相关。细胞外基质不仅可以调节T细胞的黏附、迁移等细胞运动过程,还可以调控T细胞的活化与效应功能的发挥。在细胞外基质重塑肿瘤免疫微环境的同时,免疫细胞也通过细胞因子等调控细胞外基质重塑过程。近年来,越来越多的研究聚焦于靶向细胞外基质和肿瘤免疫的联合治疗,以期控制肿瘤的发生发展。本文总结了肿瘤微环境中细胞外基质与T细胞之间的交互通讯机制以及细胞外基质调控T细胞介导的抗肿瘤免疫应答的研究进展。The expression profiles of extracellular matrix(ECM)proteins in tumor differ significantly from those in normal tissue.Aberrant deposition and remodeling of the ECM and changes in ECM physicochemical properties such as rigidity are common features of many solid tumors,and are often closely related to the therapeutic resistance.ECM can not only regulate T cell adhesion and migration,but also modulate the activation and effector function of T cells.While the ECM reshapes the tumor immune microenvironment,cytokines secreted by immune cells also regulate ECM remodeling.In recent years,combination therapy targeting the ECM and tumor immunity has attracted a lot of attention in order to control the occurrence and development of tumors.This paper summarizes the research progress of the interactive communication between the ECM and T cells in the tumor microenvironment,and the ECM-regulated anti-tumor T cell immune response.

关 键 词：细胞外基质 基底膜 T细胞 肿瘤免疫 

分 类 号：R730.5[医药卫生—肿瘤]