整合素激活蛋白Talin的生物学功能及其在肿瘤进展中的作用  

The biological function of integrin activating protein Talin and its role in tumor progression

作　　者：薄金锁 曾奕妍 张宏权[1,2] 魏潇凡 BO Jinsuo;ZENG Yiyan;ZHANG Hongquan;WEI Xiaofan(Department of Anatomy,Histology,and Embryology,School of Basic Medical Sciences Peking University,Beijing 100191,China;Peking University International Cancer Institute,Peking University,Beijing 100191,China)

机构地区：[1]北京大学基础医学院人体解剖与组织胚胎学系,北京100191 [2]北京大学国际癌症研究院,北京100191

出　　处：《生命的化学》2023年第7期1126-1136,共11页Chemistry of Life

基　　金：国家自然科学基金项目(82073240)。

摘　　要：Talin蛋白最早发现于黏着斑及片状伪足,是黏着斑的重要组成蛋白。Talin是整合素激活的关键调控因子,它直接结合整合素的胞内段并介导其激活,并同时结合胞质内的肌动蛋白细丝,是细胞感受机械力的重要蛋白。Talin作为连接细胞骨架与跨膜受体整合素的桥梁,在细胞黏附、运动和迁移等过程中发挥着关键的调控作用,参与肿瘤等疾病的发生发展。本文将对Talin的结构、翻译后修饰、生物学功能及其在疾病发生发展中的作用进行阐述。Talin was first discovered in focal adhesions and lamellipodia,and it is an important component of focal adhesions.Numerous studies have confirmed that Talin is a key regulatory factor for integrin activation.It directly binds to the cytoplasmic segment of integrin and mediates its activation,while also binding to actin filaments in the cytoplasm.Talin is a crucial protein for cells to sense mechanical force.As a bridge connecting the cell skeleton and the transmembrane receptor integrin,Talin plays a critical role in regulating fundamental processes such as cell adhesion,movement,and migration,and plays an important role in the development of diseases such as tumors.This review will discuss the structure,cellular function,and post-translational modification(PTM)of Talin,as well as its role in the occurrence and development of diseases.

关 键 词：TALIN 整合素 细胞黏附 翻译后修饰 肿瘤发生发展 

分 类 号：R730.2[医药卫生—肿瘤]