肠道微生态系统对食欲调节功能影响及机制的研究进展  

Research progress in the effects and mechanisms of intestinal microecosystem on appetite regulation

作　　者：林颖怡 逄蓬 LIN Yingyi;PANG Peng(The Second Affiliated Hospital,Guangzhou Medical University,Guangzhou 510260,China)

机构地区：[1]广州医科大学附属第二医院,广州510260

出　　处：《生命的化学》2023年第6期855-862,共8页Chemistry of Life

基　　金：国家自然科学基金青年项目(82204992);广州市基础与应用基础研究项目(202201011262);广州市中医药和中西医结合科技项目(20212A011021);广东省中医药局科研项目(20211247)。

摘　　要：肠道微生态系统与人类生理病理密切相关,目前其作为研究疾病新治疗途径的切入点,尤其在与食欲紊乱相关疾病方面受到广泛关注。随着研究的深入,学者们发现,肠道微生态通过代谢、内分泌、神经、免疫等多条途径参与对食欲的调节。本文综述了肠道微生态系统通过上述途径对宿主食欲调节功能的影响及相关机制,阐述了肠道微生物及其代谢产物对食欲和能量代谢的影响,以期对食欲相关疾病的微生物靶向疗法有所启发。Intestinal microecosystem is closely related to human physiology and pathology.The study of the intestinal microecosystem has gained significant attention as a potential breakthrough point for new treatment approaches for diseases,particularly appetite-related disorders.With the deepening of the research,researchers have discovered that the intestinal microecology played an important role in regulating appetite through various pathways such as metabolism,endocrine,nerve,and immunity.This paper aims to review the effects and mechanisms of the intestinal microecosystem on the host's appetite regulation through these pathways,and discuss the effects of gut microbiota and metabolites on appetite and energy metabolism,providing valuable insights for targeted therapies in appetite-related diseases.

关 键 词：肠道微生态 食欲调节 神经内分泌调节 

分 类 号：R574[医药卫生—消化系统]