血清VILIP-1 CXCL16联合ox-LDL预测急性缺血性脑卒中患者预后不良的价值  

Value of serum VILIP-1,CXCL16 combined with ox-LDL in predicting poor prognosis of acute ischemic stroke

作　　者：康梅娟[1] 温昌明[1] 张保朝[1] 孙军[1] 裴双 杨银雪 崔萍[1] KANG Meijuan;WEN Changming;ZHANG Baochao;SUN Jun;PEI Shuang;YANG Yinxue;CUI Ping(Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]南阳市中心医院,河南南阳473000

出　　处：《中国实用神经疾病杂志》2023年第10期1249-1253,共5页Chinese Journal of Practical Nervous Diseases

基　　金：河南省2019年科技发展计划项目(编号:192102310349)。

摘　　要：目的探讨血清VILIP-1、CXCL16结合ox-LDL预测急性缺血性脑卒中患者预后不良的价值。方法以2020-05—2021-12南阳市中心医院治疗的100例急性缺血性脑卒中患者为观察组,另取100例进行体检的健康者为对照组,采用酶联免疫法检测所有受试者血清VILIP-1、CXCL16、ox-LDL水平。依据患者的神经功能缺损情况进行量化评分,分为轻型组、中型组、重型组。采用改良Rankin量表评定患者半年内的临床预后情况,分为预后良好组、预后不良组,以患者临床预后为因变量,VILIP-1、CXCL16、ox-LDL为自变量拟合多分类或二分类Logistic回归方程,分析各指标对患者病情或临床预后的影响。结果与对照组相比,观察组血清VILIP-1、CXCL16、ox-LDL水平均显著升高(P<0.05)。与轻度组比较,中度组血清VILIP-1、CXCL16、ox-LDL水平升高(P<0.05);与中度组比较,重度组血清VILIP-1、CXCL16、ox-LDL水平升高(P<0.05)。与预后良好组比较,预后不良组血清VILIP-1、CXCL16、ox-LDL水平显著升高(P<0.05)。ILIP-1、CXCL16、ox-LDL等均是影响急性脑卒中患者疾病分级及预后的独立危险因素。VILIP-1的AUC值为0.834,灵敏度69.45%,特异性80.29%;CXCL16的AUC值为0.830,灵敏度69.38%,特异性81.02%;ox-LDL的AUC值为0.824,灵敏度69.40%,特异性80.31%;联合检测的AUC值为0.938,灵敏度83.56%,特异性93.11%。结论血清VILIP-1、CXCL16、ox-LDL水平的异常变化与疾病分型和患者预后密切相关,联合检测在急性缺血性脑卒中诊断中效能良好。Objective To probe the value of serum VILIP-1 and CXCL16 combined with ox-LDL levels in predicting poor prognosis of acute ischemic stroke.Methods One hundred patients with acute ischemic stroke treated in Nanyang Central Hospital from May 2020 to December 2021 were selected as the observation group,and 100 healthy persons who underwent physical examination in our hospital were selected as the control group.Serum levels of VILIP-1,CXCL16 and ox-LDL in all patients were detected by enzyme-linked immunoassay.The patients were divided into mild group,medium group and severe group according to the quantitative score of neuro⁃logical impairment.The modified Rankin scale was used to evaluate the clinical prognosis of patients within six months,and the patients were divided into good prognosis group and poor prognosis group.The clinical prognosis of patients was used as dependent variable and VILIP-1,CXCL16 and ox-LDL were used as independent variables to fit the multi-classification or biclassification Logistic regression equation.The influence of each index on the patient’s condition or clinical prognosis was analyzed comprehensively.Results Compared with control group,serum levels of VILIP-1,CXCL16 and ox-LDL in observation group were significantly increased(P<0.05).Compared with mild acute stroke,serum levels of VILIP-1,CXCL16 and ox-LDL were increased in moderate patients(P<0.05).Compared with moderate acute stroke,serum levels of VILIP-1,CXCL16 and ox-LDL were higher in severe stroke patients(P<0.05).Compared with the good prognosis group,the serum contents of VILIP-1,CXCL16 and ox-LDL in the poor prognosis group were significantly increased(P<0.05).ILIP-1,CXCL16 and ox-LDL were all independent risk factors affecting the disease grade and prognosis of patients with acute stroke.The AUC value of VILIP-1 was 0.834,the sensitivity was 69.45%,and the specificity was 80.29%.The AUC value,sensitivity and specificity of CXCL16 were 0.830,69.38%and 81.02%,respectively.The AUC value of ox-LDL was 0.824,the sensitivity

关 键 词：急性缺血性脑卒中 视锥蛋白样蛋白1 CXC型趋化因子配体16 氧化低密度脂蛋白 预后 血清 

分 类 号：R743.33[医药卫生—神经病学与精神病学]