乙型肝炎病毒X蛋白通过泛素-蛋白酶体系统促进乙型肝炎病毒感染和肝癌发生发展的研究进展  

Progress in the role of ubiquitin-proteasome system in hepatitis B virus X protein-mediated HBV infection and hepatocarcinogenesis

作　　者：皮雨博 陈彦猛 唐霓[1] Pi Yubo;Chen Yanmeng;Tang Ni(Key Laboratory of Molecular Biology for Infectious Diseases,Ministry of Education,Chongqing Medical University,Chongqing 400016,China;Department of Laboratory Medicine,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学感染性疾病分子生物学教育部重点实验室,重庆400016 [2]重庆医科大学检验医学院,重庆400016

出　　处：《中华微生物学和免疫学杂志》2023年第7期517-524,共8页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金(82102377,82072286,82272975);重庆市教委科学技术研究项目(KJQN202100464,KJZD-M202000401)。

摘　　要：慢性乙型肝炎病毒(hepatitis B virus,HBV)感染是导致肝癌发生发展的重要病因之一。泛素-蛋白酶体系统(ubiquitin-proteasome system,UPS)在真核细胞内介导蛋白质翻译后修饰和降解。近年来研究发现,UPS在HBV感染及相关肝癌发生发展中发挥了重要作用,通过靶向HBV X蛋白(HBV X protein,HBx)干预HBV感染或HBV相关肝癌的进展成为近年来国内外的研究热点。本文对HBx通过UPS促进HBV感染和肝癌发生发展的研究进展进行了综述。Chronic hepatitis B virus(HBV)infection is one of the leading causes of hepatocellular carcinoma(HCC).Ubiquitin-proteasome system(UPS)mediates the post-translational modification and degradation of protein in eukaryotic cells.Recent studies have revealed that UPS plays an important role in HBV infection and hepatocarcinogenesis.Targeting HBx to intervene in the progression of HBV infection or HBV-related HCC has become a research hotspot both domestically and internationally in recent years.This article reviewed the progress in HBx promoting HBV infection and hepatocarcinogenesis through UPS.

关 键 词：乙型肝炎病毒 HBX 肝癌 泛素-蛋白酶体系统 

分 类 号：R512.62[医药卫生—内科学] R735.7[医药卫生—临床医学]