MES、UCEIS联合DUBLIN评分在溃疡性结肠炎疾病管理中的应用  

Application of MES and UCEIS combined with DUBLIN score in management of ulcerative colitis

作　　者：顾林[1] 赵睿[1] 马振增[1] 邓敏[1] 郑海伦[1] 燕善军[1] 秦丹 GU Lin;ZHAO Rui;MA Zhenzeng;DENG Min;ZHENG Hailun;YAN Shanjun;QIN Dan(Department of Gastroenterology,The First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China)

机构地区：[1]蚌埠医学院第一附属医院消化内科,安徽蚌埠233004 [2]蚌埠医学院公共基础学院,安徽蚌埠233004

出　　处：《皖南医学院学报》2023年第4期364-367,共4页Journal of Wannan Medical College

基　　金：安徽省高等学校科学研究项目(2022AH051426);蚌埠医学院自然科学重点项目(BYKY2019085ZD);蚌埠医学院自然科学基金面上项目(BYKY1683)。

摘　　要：目的:评价溃疡性结肠炎(UC)内镜评分系统在疾病管理中的临床应用价值。方法:回顾性分析2016年11月~2022年11月住院的203例UC患者,另随机选取206名同期健康体检者。统计两组基线特征,分析内镜评分与临床参数之间的关系。结果:UC患者的炎症指标较健康体检者升高,差异有统计学意义。评估疾病严重程度方面,Mayo内镜评分(MES)和溃疡性结肠炎内镜严重程度指数(UCEIS)更具有优势(H=187.491、156.567,P<0.001)。UCEIS和溃疡性结肠炎管腔炎症负荷严重程度评分(DUBLIN)在评估UC患者的疾病炎症负荷方面优于MES,UCEIS预测治疗反应和升级治疗方面效能较高。结论:DUBLIN评分方法简单,操作便捷,更适合在日常临床实践中应用;UCEIS可以更好地预测是否需升级治疗,适合为UC患者制定个性化的治疗方案。Objective:To evaluate the clinical application value of endoscopic scoring systems in prospective management of ulcerative colitis(UC)disease management.Methods:Retrospective analysis was performed in 203 UC patients treated on hospitalized basis between November 2016 and November 2022,and another 206 healthy subjects undergoing physical examination during the same period were randomly recruited.Statistic analysis was made regarding the baseline characteristics of two groups and the relationship between endoscopic scores and clinical parameters.Results:The inflammatory indicators of UC patients were significantly higher than those of healthy subjects,and the difference was statistically significant.Mayo endoscopic subscore(MES)and Ulcerative Colitis Endoscopic Index of Severity(UCEIS)were more favorable to assessing disease severity(H=187.491,156.567,P<0.001).UCEIS and Degree of Ulcerative Colitis Burden of Luminal Inflammation(DUBLIN)score were superior to MES in assessing the inflammatory burden of UC patients.UCEIS was more effective in predicting treatment response and therapy upgrade.Conclusion:DUBLIN is easy and convenient to operate,which is more suitable for daily clinical practice.UCEIS can better necessity of therapy upgrade,which is suitable for designing tailored treatment plan for UC patients.

关 键 词：溃疡性结肠炎 Mayo内镜评分 溃疡性结肠炎内镜严重程度指数 溃疡性结肠炎管腔炎症负荷严重程度评分 

分 类 号：R574.62[医药卫生—消化系统]