1995至2021年河南省食管癌高发区早期食管癌占比变化趋势  

Change of the proportion of patients with early stage esophageal cancer from high-incidence of esophageal cancer in Henan Province from 1995 to 2021

作　　者：宋昕[1] 韩文莉 胡景峰 钟侃 马琳琳 王苒[1] 周福有[3] 王献增 高文俊 郭威 李爱丽[7] 郭贵周 刘志才[8] 李吉林 焦新英 常扶保 常志军 范宗民[1] 李贝[1] 韩雪娜[1] 伍玥[11] 王立东[1] SONG Xin;HAN Wenli;HU Jingfeng;ZHONG Kan;MA Linlin;WANG Ran;ZHOU Fuyou;WANG Xianzeng;GAO Wenjun;GUO Wei;LI Aili;GUO Guizhou;LIU Zhicai;LI Jilin;JIAO Xinying;CHANG Fubao;CHANG Zhijun;FAN Zongmin;LI Bei;HAN Xuena;WU Yue;WANG Lidong(State Key Laboratory of Esophageal Cancer Prevention and Treatment,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Department of Pathology and Pathophysiology,School of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001;Department of Thoracic Surgery,Anyang Tumor Hospital,Anyang,Henan 455000;Department of Oncology,Linzhou People′s Hospital,Linzhou,Henan 456550;Department of Thoracic Surgery,Linzhou People′s Hospital,Linzhou,Henan 456550;Department of Pathology,Linzhou People′s Hospital,Linzhou,Henan 456550;Department of Oncology,Linzhou Tumor Hospital,Linzhou,Henan 456550;Department of Thoracic Surgery,Linzhou Tumor Hospital,Linzhou,Henan 456550;Department of Pathology,Linzhou Esophageal Cancer Hospital,Linzhou,Henan 456592;Department of Thoracic Surgery,Linzhou Central Hospital,Linzhou,Henan 456592;Department of Gastroenterology,Henan Province People′s Hospital,Zhengzhou 450000)

机构地区：[1]郑州大学第一附属医院省部共建食管癌防治国家重点实验室,郑州450052 [2]郑州大学基础医学院病理学与病理生理学教研室,郑州450001 [3]安阳市肿瘤医院胸外科,河南安阳455000 [4]林州市人民医院肿瘤科,河南林州456550 [5]林州市人民医院胸外科,河南林州456550 [6]林州市人民医院病理科,河南林州456550 [7]林州市肿瘤医院肿瘤科,河南林州456550 [8]林州市肿瘤医院胸外科,河南林州456550 [9]林州市食管癌医院病理科,南林州456592 [10]林州市中心医院胸外科,河南林州456592 [11]河南省人民医院消化内科,郑州450000

出　　处：《郑州大学学报（医学版）》2023年第4期445-448,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省科技重大专项(161100311300);国家自然科学基金面上项目(U1804262);河南省科技攻关项目(232102311032);中原学者工作站项目(214400510025,224400510004)。

摘　　要：目的:分析1995至2021年河南省食管癌高发区5家医院就诊病例中早期食管癌占比的变化,了解高发区食管癌的防治效果。方法:对来自河南省食管癌高发区27 a间5家医院收治且有明确病理诊断的127249例食管癌病例中早期癌占比进行Joinpoint回归分析。结果:2009年食管癌病例数较1995年增加了2.4倍,而2009年至2021年病例数则逐年下降。Joinpoint分析结果显示,1995至2011年早期食管癌占比上升速度较慢,年度变化百分比(95%CI)为2.94%(1.53%~4.36%);2011年以后则上升速度增快,年度变化百分比(95%CI)为12.27%(9.27%~15.35%)。结论:食管癌一级预防和二级预防措施的推广使高发区食管癌病例数明显减少,早期癌检出率大幅度提升。Aim:To clarify the change of the proportion of early stage esophageal cancer cases in 5 hospitals from the high-incidence area of esophageal cancer in Henan Province from 1995 to 2021,and explore the prevention and treatment effects.Methods:A total of 127249 esophageal cancer cases with definite pathological diagnosis admitted to 5 hospitals from the high-incidence area of esophageal cancer in Henan Province over the past 27 years was enrolled,and the distribution characteristics of different clinical phenotypes were collected.Joinpoint analysis was conducted on the proportion of early stage esophageal cancer cases.Results:In 2009,the number of esophageal cancer cases increased by 2.4 times compared with 1995,while from 2009 to 2021,the number of cases decreased year by year.Joinpoint analysis showed that the proportion of early stage esophageal cancer cases increased slowly from 1995 to 2011,with an annual percentage change(95%CI)of 2.94%(1.53%-4.36%);after 2011,the proportion increased rapidly,with annual percentage change(95%CI)of 12.27%(9.27%-15.35%).Conclusion:The promotion and application of primary and secondary prevention measures for esophageal cancer in high-incidence areas have significantly reduced the number of esophageal cancer patients cases in hospitals,and increased the detection rate of early stage cancer.

关 键 词：食管癌 早期癌 高发区 河南省 

分 类 号：R735.1[医药卫生—肿瘤]