肺癌放疗后放射性肺炎患者T淋巴细胞亚群、中性粒细胞与淋巴细胞比值的测定  

Determination of T lymphocyte subsets and neutrophil to lymphocyte ratio of lung cancer patients with radiation pneumonitis after radiotherapy

作　　者：张伟[1] 任丽丽 宋艺玲 江超 黄锐 ZHANG Wei;REN Lili;SONG Yiling;JIANG Chao;HUANG Rui(Department of Radiotherapy,Fuyang People′s Hospital,Fuyang,Anhui 236000)

机构地区：[1]阜阳市人民医院放疗科,安徽阜阳236000

出　　处：《郑州大学学报（医学版）》2023年第4期544-548,共5页Journal of Zhengzhou University(Medical Sciences)

基　　金：阜阳市自筹经费科技项目(FK20281039)。

摘　　要：目的:分析肺癌放疗后放射性肺炎(RP)患者T淋巴细胞亚群、中性粒细胞与淋巴细胞比值(NLR)的变化和意义。方法:选取2018年8月至2022年6月在阜阳市人民医院收治的肺癌调强放射治疗4~8周的患者72例,放疗后6个月内发生RP 11例。收集患者放疗前的一般资料;放疗前,放疗完成后1、2、3个月,检测血液CD3^(+)、CD4^(+)、CD8^(+)T淋巴细胞比例,中性粒细胞计数,计算CD4^(+)/CD8^(+)和NLR。结果:RP组KPS评分≥80分患者比例(36.36%)小于未RP组(78.69%),糖尿病患者比例(45.45%)大于未RP组(11.48%),差异均有统计学意义(P<0.05)。与放疗前比较,放疗后两组CD3^(+)、CD4^(+)T淋巴细胞比例及CD4^(+)/CD8^(+)均降低,NLR升高(P<0.05);与未RP组比较,RP组CD3^(+)、CD4^(+)T淋巴细胞比例更低,NLR更高(P<0.05)。结论:KPS评分和糖尿病可能影响肺癌放疗后RP的发生,T细胞亚群、NLR对肺癌放疗后RP的发生可能有预测价值。Aim:To analyze the changes of T lymphocyte subsets and neutrophil to lymphocyte ratio(NLR)of lung cancer patients with radiation pneumonitis(RP)after radiotherapy.Method:A total of 72 lung cancer patients receiving intensity modulated radiotherapy for 4-8 weeks in Fuyang People′s Hospital from August 2018 to June 2022 were selected,and 11 cases occurred RP within 6 months of follow-up.General data of all the patients were collected.Before radiotherapy and 1,2 and 3 months after radiotherapy,the proportion of CD3^(+),CD4^(+)and CD8^(+)T lymphocytes,the count of neutrophils were detected,and CD4^(+)/CD8^(+)and NLR were calculated.Results:The proportion(36.36%)of patients with KPS score≥80 in RP group was significantly lower than that(78.69%)in non-RP group,the proportion(45.45%)of patients with diabetes mellitus was significantly higher than that(11.48%)in non-RP group,and the differences were significant(P<0.05).Compared with those before radiotherapy,the proportion of CD3^(+),CD4^(+)T lymphocytes and CD4^(+)/CD8^(+)in both groups after radiotherapy decreased(P<0.05),while NLR increased(P<0.05).The proportion of CD3^(+),CD4^(+)T lymphocytes in RP group were significantly lower,and NLR was higher than those in the non-RP group(P<0.05).Conclusion:KPS score and diabetes mellitus may affect the occurrence of RP after radiotherapy for patients with lung cancer.T lymphocyte subsets and NLR may have predictive value for the occurrence of RP.

关 键 词：T淋巴细胞亚群 中性粒细胞与淋巴细胞比值 肺癌 放射性肺炎 

分 类 号：R734.2[医药卫生—肿瘤]