Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse  

作　　者：Tingting Song Wusa Qin Zeliang Lai Haoyu Li Daihan Li Baojia Wang Wuquan Deng Tingzhang Wang Liming Wang Rui Huang 

机构地区：[1]Institute of Molecular Physiology,Shenzhen Bay Laboratory,Shenzhen,Guangdong,China [2]Center for Neurointelligence,School of Medicine,Chongqing University,Chongqing,China [3]Department of Endocrinology and Nephrology,Chongqing University Central Hospital,Chongqing Emergency Medical Center,Chongqing,China [4]Department of General Surgery,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang,China

出　　处：《Cell Research》2023年第6期434-447,共14页细胞研究（英文版）

基　　金：the National Key R&D Program of China(2019YFA0801900 and 2019YFA0802400 to L.W.);the National Natural Science Foundation of China(32071006 to L.W.and 32271008 to R.H.);the startup funds from Shenzhen Bay Laboratory to L.W.

摘　　要：Obesity imposes a global health threat and calls for safe and effective therapeutic options.Here,we found that protein-rich diet significantly reduced body fat storage in fruit flies,which was largely attributed to dietary cysteine intake.Mechanistically,dietary cysteine increased the production of a neuropeptide FMRFamide(FMRFa).Enhanced FMRFa activity simultaneously promoted energy expenditure and suppressed food intake through its cognate receptor(FMRFaR),both contributing to the fat loss effect.In the fat body,FMRFa signaling promoted lipolysis by increasing PKA and lipase activity.In sweet-sensing gustatory neurons,FMRFa signaling suppressed appetitive perception and hence food intake.We also demonstrated that dietary cysteine worked in a similar way in mice via neuropeptide FF(NPFF)signaling,a mammalian RFamide peptide.In addition,dietary cysteine or FMRFa/NPFF administration provided protective effect against metabolic stress in flies and mice without behavioral abnormalities.Therefore,our study reveals a novel target for the development of safe and effective therapies against obesity and related metabolic diseases.

关 键 词：CYSTEINE protective hence 

分 类 号：Q517[生物学—生物化学]