乳腺癌患者化疗期间抑郁状态的相关因素分析  

Analysis of related factors of depression state in breast cancer patients during chemotherapy

作　　者：冉启志 冉文 谭月[3] 朱宁[3] 吴绍勇[3] RAN Qizhi;RAN Wen;TAN Yue;ZHU Ning;WU Shaoyong(School of Medicine and Life Science,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610041,China;Health Management Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China;Department of Head,Neck and Mammary Gland Oncology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China)

机构地区：[1]成都中医药大学医学与生命科学学院,四川成都610041 [2]四川大学华西医院健康管理中心,四川成都610041 [3]四川大学华西医院头颈乳腺肿瘤科,四川成都610041

出　　处：《现代医药卫生》2023年第16期2742-2745,2751,共5页Journal of Modern Medicine & Health

基　　金：四川省科技厅科技支撑计划(2015SZ0157);成都中医药大学“杏林学者”学科人才提升计划医院专项课题(2018yky13)。

摘　　要：目的探讨乳腺癌患者化疗期间抑郁状态的危险因素及血清C反应蛋白(CRP)与抑郁状态的相关性。方法收集2018年5月至2021年4月四川大学华西医院头颈乳腺肿瘤科收治的217例初诊乳腺癌患者的临床资料,采用logistic多因素回归模型分析乳腺癌患者化疗期间抑郁状态的危险因素及血清CRP与乳腺癌患者抑郁状态的关系。结果在217例初诊乳腺癌患者中,筛查出抑郁状态28例(12.90%)。单因素分析结果显示,患者病理分期、疼痛、睡眠状态、血清CRP水平与抑郁有关(P<0.05);多因素分析结果显示,血清CRP水平升高和失眠与患者抑郁状态均有关(P<0.05)。结论初诊乳腺癌患者抑郁状态的发生率较高,患者失眠、血清CRP水平升高是初诊乳腺癌患者抑郁状态的独立危险因素。Objective To investigate the risk factors of depression in breast cancer patients during chemotherapy and the correlation between serum C-reactive protein(CRP)and depression state.Methods Clinical data of 217 newly diagnosed breast cancer patients admitted to Department of Head,Neck and Mammary Gland Oncology of West China Hospital of Sichuan University from May 2018 to April 2021 were collected.Logistic multivariate regression model was used to analyze the risk factors of depression state during chemotherapy and the relationship between serum CRP and depression state in breast cancer patients.Results Among the 217 newly diagnosed breast cancer patients,28(12.90%)cases were found to be in depression state.Univariate analysis showed that pathological stage,pain,sleep state,and serum CRP level were related to depression(P<0.05).The results of multivariate analysis showed that elevated serum CRP level and insomnia were correlated with depression state(P<0.05).Conclusion The incidence of depression state is high in newly diagnosed breast cancer patients.Insomnia and elevated serum CRP level are independent risk factors for depression in newly diagnosed breast cancer patients.

关 键 词：C反应蛋白 乳腺癌 抑郁状态 化学治疗 危险因素 

分 类 号：R737.9[医药卫生—肿瘤]