广西壮族聚居区宫颈癌及癌前病变患者HPV感染基因型别分布研究  

Genotypes Distribution of HPV Infection in 333 Patients with Cervical Cancer and Precancerous Lesions in Zhuang Inhabited Areas of Guangxi

作　　者：王柏莲 林青 廖瑜 蒋诚传 李玉芸 石姗以 李泰阶 WANG Bailian;LIN Qing;LIAO Yu(Wuming Hospital of Guangxi Medical University,Nanning,530199)

机构地区：[1]广西医科大学附属武鸣医院,530199

出　　处：《实用癌症杂志》2023年第9期1461-1465,共5页The Practical Journal of Cancer

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(编号:Z20200348)。

摘　　要：目的分析广西壮族聚居区宫颈癌及癌前病变患者人乳头瘤病毒(HPV)感染情况,为制定该地区宫颈癌筛查及预防策略提供理论依据。方法收集经病理明确诊断为宫颈上皮内瘤变和宫颈癌的患者333例,采用导流杂交基因芯片技术对21种HPV型别进行分型检测。结果333例患者中HPV总检出率为97.60%;LSIL组、HSIL组和宫颈癌组的检出率分别为98.89%、98.60%和95.00%。总病例检出前五位的基因型别为HPV16、HPV52、HPV58、HPV18和HPV51。3组HPV单一感染率分别为64.44%、67.83%、79.00%,多重感染率分别为34.44%、30.77%、16.00%,LSIL与HSIL比较无统计学意义(P>0.05),LSIL、HSIL与宫颈癌比较有统计学意义(P<0.01和P<0.05)。3组伴有16、18型(含16、18的单一或多重感染)感染率分别为:22.22%、52.45%、77.00%,单纯其它型别(除16、18型以外的其它型别)感染率为:76.67%、46.15%、18.00%,3组比较有统计学意义(P<0.01)。LSIL和HSIL检出率最高的年龄段为30~49岁,分别为74.45%和69.93%;宫颈癌组检出率最高的年龄段是50~69岁,为59.00%。结论广西壮族聚居区女性宫颈癌及癌前病变的发生与HPV高危型别密切相关,常见型别为HPV16、HPV52、HPV58、HPV18、HPV51。多重感染并未增加宫颈病变程度,但感染伴有16、18型的患者会增加宫颈病变恶性程度的风险。LSIL和HSIL好发年龄段为30~49岁,应加强这个年龄段妇女的宫颈癌筛查力度;宫颈癌组好发年龄段为50~69岁,要重视该年龄段女性的宫颈癌工作筛查。对这些患者临床应加强随访,及时有效干预,以降低宫颈癌及癌前病变的发生。Objective To analyze the human papillomavirus(HPV)infection in patients with cervical cancer and precancerous lesions in Guangxi Zhuang inhabited areas,Provide theoretical basis for developing cervical cancer screening and prevention strategies in the region.Methods 333 patients with cervical intraepithelial neoplasia and cervical cancer were collected,and 21 HPV types were detected by flow-through hybridization gene chip technology.Results The overall detection rate of HPV in 333 patients was 97.60%,and the detection rate of LSIL group,HSIL group and cervical cancer group were 98.89%,98.60%and 95.00%,respectively.The top 5 genotypes positive detected in all patients were HPV16,HPV52,HPV58,HPV18 and HPV51,The single infection rates of HPV in the three groups were 64.44%,67.83%and 79.00%respectively,and the multiple infection rates were 34.44%,30.77%and 16.00%respectively.There was no significant difference between LSIL and HSIL(P>0.05),but there was significant difference between LSIL,HSIL and T cervical cancer(P<0.01 and P<0.05).The infection rates of type 16 and 18(including single or multiple infection of type 16 and 18)in the three groups were 22.22%,52.45%and 77.00%.The infection rates of other types(except type 16 and 18)were 76.67%,46.15%and 18.00%.There was significant difference among the three groups(P<0.01).The age group with the highest detection rates for LSIL and HSIL was 30~49 years old,accounting for 74.45%and 69.93%,respectively.The age group with the highest detection rate for cervical cancer was 50~69 years old,accounting for 59.00%.Conclusion The incidence of cervical cancer and precancerous lesions in women living in Zhuang ethnic minority areas in Guangxi is closely related to the high-risk types of HPV.The common types are HPV16,HPV52,HPV58,HPV18 and HPV51.Multiple infection does not increase the degree of cervical lesions,but patients with type 16 and 18 infection will have the risk of increasing the malignant degree of cervical lesions.The age group at which LSIL and HSIL are prone to occ

关 键 词：人乳头瘤病毒 宫颈癌前病变 宫颈癌 筛查 分型检测 

分 类 号：R737.33[医药卫生—肿瘤]