口腔鳞状细胞癌组织中PTEN、VEGF表达及其临床意义  

Expression and Clinical Significance of PTEN and VEGF in Oral Squamous Cell Carcinoma Tissue

作　　者：陈青 孙强[1] 冉芳 CHEN Qing;SUN Qiang;RAN Fang(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2023年第9期1473-1476,共4页The Practical Journal of Cancer

摘　　要：目的探讨口腔鳞状细胞癌(OSCC)组织中蛋白酪氨酸磷酸酶基因(PTEN)与血管内皮生长因子(VEGF)的表达及临床意义。方法选取61例OSCC患者,收集全部患者肿瘤组织标本(病灶组)以及癌旁正常口腔黏膜组织标本(对照组)。采用免疫组织化学法,检测PTEN与VEGF表达情况,并分析PTEN、VEGF表达与OSCC患者不同临床病理特征的关系。结果病灶组的PTEN阳性表达率低于对照组,VEGF阳性表达率高于对照组,有统计学差异(P<0.05);OSCC患者的PTEN、VEGF阳性表达与年龄、性别无关(P>0.05);OSCC患者的PTEN、VEGF阳性表达与临床分期、分化程度、淋巴结转移有关(P<0.05)。结论OSCC组织中PTEN阳性表达率较低,VEGF阳性表达率较高,PTEN、VEGF与患者的临床分期、分化程度、淋巴结转移密切相关,临床需加强对PTEN、VEGF表达水平的监测,以此为参考及时施行有效的诊治措施,以尽早控制患者病情,延长生存周期。Objective To investigate the expression and clinical significance of protein tyrosine phosphatase gene(PTEN)and vascular endothelial growth factor(VEGF)in oral squamous cell carcinoma(OSCC)tissue.Methods 61 OSCC patients diagnosed and treated were selected,and tumor tissue samples(lesion group)and normal oral mucosa tissue samples(control group)were collected from all patients.Immunohistochemical methods were used to detect the expression of PTEN and VEGF,and the relationship between PTEN and VEGF expression and different clinical and pathological characteristics of OSCC patients was analyzed.Results The positive expression rate of PTEN in the lesion group was lower than that in the control group,while the positive expression rate of VEGF was higher than that in the control group,with a statistical difference(P<0.05);The positive expression of PTEN and VEGF in OSCC patients was not related to age and gender(P>0.05);The positive expression of PTEN and VEGF in OSCC patients was related to clinical stage,degree of differentiation,and lymph node metastasis(P<0.05).Conclusion The positive expression rate of PTEN and VEGF in OSCC tissues is relatively low,while the positive expression rate of VEGF is relatively high.PTEN and VEGF are closely related to the clinical stage,differentiation degree,and lymph node metastasis of patients.It is necessary to strengthen the monitoring of PTEN and VEGF expression levels in clinical practice,taking this as a reference and implementing effective diagnosis and treatment measures in a timely manner to control the patient's condition as soon as possible and prolong their survival cycle.

关 键 词：口腔鳞状细胞癌 蛋白酪氨酸磷酸酶基因 血管内皮生长因子 肿瘤组织 病理特征 

分 类 号：R739.8[医药卫生—肿瘤]