单向式全胸腔镜肺叶切除术治疗早期非小细胞肺癌的效果分析  

Analysis of the Effect of One-way Total Thoracoscopic Lobectomy for Early Non-small Cell Lung Cancer

作　　者：刘盈盈 靳水灵 龚帅[1] LIU Yingying;JIN Shuiling;GONG Shuai(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2023年第9期1518-1521,共4页The Practical Journal of Cancer

摘　　要：目的探讨单向式全胸腔镜肺叶切除术治疗早期非小细胞肺癌(NSCLC)的临床效果及安全性。方法选取76例早期NSCLC患者,按随机数字表法分为2组,各38例。对照组接受开放式肺叶切除术治疗,观察组予以单向式全胸腔镜肺叶切除术治疗,持续观察至患者出院。比较2组手术情况、肿瘤标志物水平、应激指标及并发症发生情况。结果观察组手术时间、切口长度、术后引流时间及住院时间为(115.62±10.39)min、(7.13±1.04)cm、(3.28±0.45)d、(10.53±2.06)d,出血量及术后疼痛评分为(118.96±10.48)mL、(3.45±0.51)分,低于对照组,差异有统计学意义(P<0.05)。观察组术后癌胚抗原(CEA)[(9.85±1.14)ng/mL]、糖类抗原50(CA50)[(11.32±2.05)U/mL]、细胞角质蛋白19片段抗原21-1(CYFRA21-1)[(2.01±0.42)ng/mL]、皮质醇(COR)[(86.89±7.15)ng/mL]、前列腺素E2(PGE2)[(146.96±13.82)pg/mL]水平低于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论单向式全胸腔镜肺叶切除术治疗早期NSCLC效果更佳,能减少术中出血量,降低COR、PGE2水平,缩短住院时间,加快肿瘤标志物水平复常,且并发症少。Objective To investigate the clinical effect and safety of one-way total thoracoscopic lobectomy for early non-small cell lung cancer(NSCLC).Methods 76 early NSCLC patients were divided into 2 groups,38 each.The control group was treated with open lobectomy,and the observation group underwent one-way total thoracoscopic lobectomy,and was continuously observed until the patient was discharged.The surgical conditions,levels of tumor markers,stress indicators,and complications were compared between the 2 groups.Results The operation time,incision length,postoperative drainage time and hospital stay were(115.62±10.39)min,(7.13±1.04)cm,(3.28±0.45)d,(10.53±2.06)d,Bleeding volume and postoperative pain scores were(118.96±10.48)mL,(3.45±0.51)points,Lower than that in the control group,The difference was significant(P<0.05);The levels of postoperative carcinomoembryonic antigen(CEA)[(9.85±1.14)ng/mL],sugar antigen 50(CA50)[(11.32±2.05)U/mL],cytokeratin 19 fragment antigen 21-11-1(CYFRA21-1)[(2.01±0.42)ng/mL],cortisol(COR)[(86.89±7.15)ng/mL],prostaglandin E2(PGE2)[(146.96±13.82)pg/mL]were lower than the control group,The difference was significant(P<0.05);The complication rate was lower in the observed group than in the control group,The difference was significant(P<0.05).Conclusion One-way total thoracoscopic lobectomy is effective for early NSCLC,it can reduce intraoperative bleeding,reduce COR and PGE2 levels,shorten hospital stay,accelerat the normalization of tumor markers with fewer complications.

关 键 词：非小细胞肺癌 单向式全胸腔镜 肺叶切除术 肿瘤标志物 

分 类 号：R734.2[医药卫生—肿瘤]