脂必泰胶囊联合匹伐他汀治疗冠心病合并糖尿病的疗效观察  

Effects of Zhibitai capsule combined with pitavastatin calcium tablets on coronary heart disease complicated with diabetes mellitus

作　　者：张静 付伟 邓彬 苏浩 Zhang Jing;Fu Wei;Deng Bin;Su Hao(Fourth Department of Cardiology,The Third Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000,Liaoning Province,China;Chengdu Di'ao Pharmaceutical Group Co.,Ltd.,Chengdu 640041,Sichuan Province,China)

机构地区：[1]锦州医科大学附属第三医院心内四科,锦州121000 [2]成都地奥制药集团有限公司,成都610041

出　　处：《中国基层医药》2023年第8期1199-1204,共6页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察脂必泰胶囊联合匹伐他汀钙片对冠心病合并糖尿病患者血脂、血糖、糖化血红蛋白的影响。方法选取2017年1月至2020年6月锦州医科大学附属第三医院收治的冠心病合并糖尿病患者100例,根据治疗方法不同分为对照组50例和观察组50例。两组均给予匹伐他汀钙片等常规治疗。对照组在常规治疗基础上给予匹伐他汀钙片,观察组在常规治疗基础上给予脂必泰胶囊联合匹伐他汀钙片。比较两组治疗6个月后三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹葡萄糖(FPG)、糖化血红蛋白(GHb)水平。结果治疗后,观察组TG为(4.26±0.67)mmol/L、TC为(1.85±0.38)mmol/L、LDL-C为(3.16±0.27)mmol/L、FPG为(8.29±1.07)mmol/L、GHb为(8.20±0.77)%,对照组分别为(4.50±0.39)mmol/L、(1.99±0.19)mmol/L、(3.28±0.27)mmol/L、(8.80±0.66)mmol/L、(8.54±0.74)%,两组均低于治疗前(对照组:t=19.56、14.60、10.66、8.60、10.18,观察组:t=15.04、14.68、11.36、12.36、12.89,均P<0.05),观察组均低于对照组,差异均有统计学意义(t=-2.12、-2.23、2.26、-2.84、-2.44,均P<0.05)。治疗后,观察组HDL-C为(1.16±0.18)mmol/L,对照组为(1.09±0.13)mmol/L,两组均高于治疗前(对照组:t=-11.10,观察组:t=-11.07,P<0.05),观察组高于对照组,差异有统计学意义(t=2.11,P<0.05)。结论脂必泰胶囊联合匹伐他汀钙片可显著改善冠心病合并糖尿病患者的血脂、血糖水平。Objective To investigate the effects of Zhibitai capsule combined with pitavastatin calcium tablets on blood lipids,blood glucose,and glycated hemoglobin in patients with coronary heart disease complicated by diabetes mellitus.Methods A total of 100 patients with coronary heart disease and diabetes mellitus who received treatment in The Third Affiliated Hospital of Jinzhou Medical University from January 2017 to June 2020 were included in this study.They were divided into a control group(n=50)and an observation group(n=50)according to different treatment methods.Both groups were given conventional treatment such as pitavastatin calcium tablets.The control group was given pitavastatin calcium tablets based on conventional treatment.The observation group was given Zhibitai capsule combined with pitavastatin calcium tablets based on conventional treatment.After 6 months of treatment,serum levels of triacylglycerol,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,fasting plasma glucose,and glycated hemoglobin were compared between the two groups.Results After treatment,serum levels of triacylglycerol,total cholesterol,low-density lipoprotein cholesterol,fasting plasma glucose,glycated hemoglobin in the observation group were(4.26±0.67)mmol/L,(1.85±0.38)mmol/L,(3.16±0.27)mmol/L,(8.29±1.07)mmol/L,and(8.20±0.77)%,respectively,and they were(4.50±0.39)mmol/L,(1.99±0.19)mmol/L,(3.28±0.27)mmol/L,(8.80±0.66)mmol/L,(8.54±0.74)%,respectively in the control group.After treatment,these indices in each group were decreased compared with those before treatment(control group:t=19.56,14.60,10.66,8.60,10.18;observation group:t=15.04,14.68,11.36,12.36,12.89,all P<0.05).After treatment,these indices in the observation group were significantly lower than those in the control group(t=-2.12,-2.23,2.26,-2.84,-2.44,all P<0.05).After treatment,the level of high-density lipoprotein cholesterol in the observation and control groups was(1.16±0.18)mmol/L and(1.09±0.13)mmol/L,respectively.Afte

关 键 词：冠心病 糖尿病 脂必泰胶囊 匹伐他汀钙片 2型糖尿病 血脂 红曲 泽泻 山楂 白术 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]